衰老对牙周软组织内稳态的影响：一篇叙述性综述

Kim Yu Gyung, Lee Sang Min, Bae Sungeun, Park Taejun, Kim Hyeonjin, Jang Yujeong, Moon Keonwoo, Kim Hyungmin, Lee Kwangmin, Park Joonyoung, Byun Jin-Seok, Kim Do-Yeon

Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea.

Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, Korea.

J Pers Med. 2021 Jan 18;11(1):58. doi: 10.3390/jpm11010058.

Aging is characterized by a progressive decline or loss of physiological functions, leading to increased susceptibility to disease or death. Several aging hallmarks, including genomic instability, cellular senescence, and mitochondrial dysfunction, have been suggested, which often lead to the numerous aging disorders. The periodontium, a complex structure surrounding and supporting the teeth, is composed of the gingiva, periodontal ligament, cementum, and alveolar bone. Supportive and protective roles of the periodontium are very critical to sustain life, but the periodontium undergoes morphological and physiological changes with age. In this review, we summarize the current knowledge of molecular and cellular physiological changes in the periodontium, by focusing on soft tissues including gingiva and periodontal ligament.

衰老的特征是生理功能逐渐衰退或丧失，导致对疾病或死亡的易感性增加。有人提出了几个衰老标志，包括基因组不稳定、细胞衰老和线粒体功能障碍，这些往往会导致众多衰老相关疾病。牙周组织是围绕并支持牙齿的复杂结构，由牙龈、牙周韧带、牙骨质和牙槽骨组成。牙周组织的支持和保护作用对维持生命至关重要，但牙周组织会随着年龄的增长而发生形态和生理变化。在这篇综述中，我们通过关注包括牙龈和牙周韧带在内的软组织，总结了牙周组织分子和细胞生理变化的现有知识。