School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan 2308, New South Wales, Australia.
Institute for Resilient Regions, Springfield Central, University of Southern Queensland, Springfield Central 4300, Queensland, Australia.
Nutrients. 2020 Mar 20;12(3):828. doi: 10.3390/nu12030828.
Deficits in the cerebral microcirculation contribute to age-related cognitive decline. In a pilot study of postmenopausal women, we found that supplementation with a low dose of resveratrol, a phytoestrogen, for 14 weeks improved cerebrovascular and cognitive functions. We have since undertaken a larger, longer term study to confirm these benefits. Postmenopausal women aged 45-85 years ( = 129) were randomized to take placebo or 75 mg trans-resveratrol twice daily for 12 months. Effects on cognition, cerebral blood flow, cerebrovascular responsiveness (CVR) and cardiometabolic markers (blood pressure, diabetes markers and fasting lipids) were assessed. Compared to placebo, resveratrol improved overall cognitive performance ( < 0.001) and attenuated the decline in CVR to cognitive stimuli ( = 0.038). The latter effect was associated with reduction of fasting blood glucose (r = -0.339, = 0.023). This long-term study confirms that regular consumption of resveratrol can enhance cognitive and cerebrovascular functions in postmenopausal women, with the potential to slow cognitive decline due to ageing and menopause.
大脑微循环的缺陷会导致与年龄相关的认知能力下降。在一项针对绝经后妇女的初步研究中，我们发现，补充低剂量白藜芦醇（一种植物雌激素）14 周可以改善脑血管和认知功能。此后，我们进行了一项更大、更长期的研究以证实这些益处。将 45-85 岁的绝经后妇女（n = 129）随机分为安慰剂组或每日两次 75mg 反式白藜芦醇组，疗程 12 个月。评估认知、脑血流、脑血管反应性（CVR）和心脏代谢标志物（血压、糖尿病标志物和空腹血脂）的变化。与安慰剂相比，白藜芦醇可改善整体认知表现（<0.001），并减弱 CVR 对认知刺激的下降（=0.038）。后一种效果与空腹血糖降低有关（r = -0.339，=0.023）。这项长期研究证实，定期摄入白藜芦醇可以增强绝经后妇女的认知和脑血管功能，并有潜力减缓因衰老和绝经导致的认知能力下降。
