Bernhard-Heine-Center for Locomotion Research, Department of Orthopedics, Julius-Maximilians-University Würzburg, 97076 Würzburg, Germany.
Institute for Human Genetics, Biocenter, Julius-Maximilians-University Würzburg, 97074 Würzburg, Germany.
Int J Mol Sci. 2021 Jan 18;22(2):919. doi: 10.3390/ijms22020919.
This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here.
这篇综述总结了关于外切酶组织非特异性碱性磷酸酶（TNAP）的重要信息，并简要介绍了由 TNAP 编码基因的突变导致的罕见疾病低磷酸酯酶症（HPP）的症状、诊断和治疗。我们强调了 TNAP 的作用超出了其在矿化过程中的已知贡献。因此，本文主要介绍了该酶对神经系统中中枢分子过程和炎症的影响。
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