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在东欧国家,下尿路症状与治疗相关行为之间的关系:来自 LUTS POLAND 研究的结果。

Relationship between Lower Urinary Tract Symptoms and Treatment-Related Behavior in an Eastern European Country: Findings from the LUTS POLAND Study.

机构信息

Department of Urology, Jagiellonian University Medical College, 30-688 Krakow, Poland.

出版信息

Int J Environ Res Public Health. 2021 Jan 18;18(2):785. doi: 10.3390/ijerph18020785.

DOI:10.3390/ijerph18020785
PMID:33477665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7831922/
Abstract

The aim of this study was to investigate the effect of lower urinary tract symptoms (LUTS) on behavior related to treatment of Polish adults aged ≥ 40 years. We conducted a computer-assisted telephone survey with a study sample stratified by age, sex, and place of residence (type, size, urban versus rural) reflecting the entire Polish population. Participants rated the frequency and symptom-specific bother of individual LUTS and their effects on seeking and receiving treatment, treatment satisfaction, and treatment continuation. We adjusted multiple logistic regression models to analyze the simultaneous effects of predictor variables on each dependent variable. Overall, 6005 participants completed the interview. One third (29.6-33.5%) of participants with LUTS were seeking treatment, and 24.0-26.4% received treatment. There was no difference in treatment seeking and receiving between urban and rural areas. Whereas storage and voiding symptoms were significantly related to treatment seeking by both men and women, treatment receiving correlated only with voiding symptoms in men and only with storage symptoms in women. Most respondents who received treatment were satisfied; treatment dissatisfaction was related to the presence of storage symptoms in both men and women. Only 50% of all participants continued their treatment; discontinuation of treatment was statistically more prevalent for women than for men. This investigation, the first population-representative study performed in Eastern Europe, revealed a low frequency of seeking treatment for LUTS. In addition, symptoms that inclined participants to seek treatment might not have been adequately addressed by the treatment they received. We also found a relatively high rate of treatment discontinuation. Clearly, there is a need for both improved patient education about LUTS treatment and a need for increased clinician awareness of the coexistence of different symptoms in men and women plus proactive evaluation by physicians for all types of LUTS and associated bother.

摘要

本研究旨在探讨下尿路症状(LUTS)对波兰≥40 岁成年人治疗行为的影响。我们采用计算机辅助电话调查,以年龄、性别和居住地(类型、大小、城市与农村)分层研究样本,反映整个波兰人口。参与者评估了个体 LUTS 的频率和症状特异性困扰,以及它们对寻求和接受治疗、治疗满意度和治疗延续的影响。我们调整了多变量逻辑回归模型,以分析预测变量对每个因变量的综合影响。 总体而言,6005 名参与者完成了访谈。三分之一(29.6-33.5%)有 LUTS 的参与者正在寻求治疗,24.0-26.4%接受了治疗。城乡地区之间的治疗寻求和接受没有差异。尽管男性和女性的存储和排尿症状均与治疗寻求显著相关,但男性仅与排尿症状相关,女性仅与存储症状相关。大多数接受治疗的受访者表示满意;治疗不满意与男性和女性的存储症状均相关。仅有 50%的参与者继续接受治疗;与男性相比,女性的治疗中断率统计学上更高。这项在东欧进行的首次代表性研究发现,LUTS 的治疗寻求频率较低。此外,促使参与者寻求治疗的症状可能没有得到他们所接受的治疗的充分解决。我们还发现治疗中断率相对较高。显然,需要加强对 LUTS 治疗的患者教育,提高临床医生对男性和女性不同症状共存的认识,并由医生主动评估所有类型的 LUTS 和相关困扰。

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本文引用的文献

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Sci Rep. 2020 Nov 13;10(1):19819. doi: 10.1038/s41598-020-76846-0.
2
Impact of OAB symptoms on work, quality of life and treatment-seeking behavior in Brazil.巴西 OAB 症状对工作、生活质量和治疗寻求行为的影响。
Curr Med Res Opin. 2020 Aug;36(8):1403-1415. doi: 10.1080/03007995.2020.1760806. Epub 2020 May 14.
3
Impact of LUTS on treatment-related behaviors and quality of life: A population-based study in Brazil.下尿路症状对治疗相关行为和生活质量的影响:巴西的一项基于人群的研究。
Neurourol Urodyn. 2019 Aug;38(6):1579-1587. doi: 10.1002/nau.24004. Epub 2019 Apr 29.
4
Mitochondrial DNA variability of the Polish population.波兰人群的线粒体 DNA 多态性。
Eur J Hum Genet. 2019 Aug;27(8):1304-1314. doi: 10.1038/s41431-019-0381-x. Epub 2019 Mar 21.
5
How long do we have to treat overactive bladder syndrome (OAB)? A questionnaire survey of Canadian urologists and gynecologists.我们需要治疗膀胱过度活动症(OAB)多长时间?一项针对加拿大泌尿科医生和妇科医生的问卷调查。
Can Urol Assoc J. 2018 Sep;12(9):E378-E383. doi: 10.5489/cuaj.5032.
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The prevalence of lower urinary tract symptoms (LUTS) in Brazil: Results from the epidemiology of LUTS (Brazil LUTS) study.巴西下尿路症状(LUTS)的流行情况:LUTS 流行病学研究(巴西 LUTS)的结果。
Neurourol Urodyn. 2018 Apr;37(4):1356-1364. doi: 10.1002/nau.23446. Epub 2017 Nov 6.
7
Persistence and adherence with mirabegron vs antimuscarinics in overactive bladder: Retrospective analysis of a UK General Practice prescription database.米拉贝隆与抗毒蕈碱药物治疗膀胱过度活动症的持续性和依从性:对英国全科医疗处方数据库的回顾性分析。
Int J Clin Pract. 2017 Oct;71(10). doi: 10.1111/ijcp.12996. Epub 2017 Sep 14.
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Reasons for Seeking Clinical Care for Lower Urinary Tract Symptoms: A Mixed Methods Study.寻求下尿路症状临床治疗的原因:一项混合方法研究。
J Urol. 2018 Feb;199(2):528-535. doi: 10.1016/j.juro.2017.07.067. Epub 2017 Jul 20.
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