Molín Jéssica, Mendonça Fábio S, Henderson Eileen E, Nyaoke Akinyi C, Ramírez Gustavo A, Navarro Mauricio A, Uzal Francisco A, Asín Javier
Animal Science Department, University of Lleida, Lleida 25198, Spain.
Laboratory of Animal Diagnosis, DMFA/UFRPE, Recife, Pernambuco 52171-900, Brazil.
Animals (Basel). 2021 Jan 18;11(1):229. doi: 10.3390/ani11010229.
Infectious and parasitic agents have been frequently associated with debilitating and wasting conditions in sheep. The prevalence of these agents has probably undermined the role of toxic causes as contributors to such disorders. In addition, many of these intoxications frequently produce acute clinical disease with specific and characteristic lesions, thus a causal relationship with the toxic substance may be relatively easy to establish. However, persistent exposure to some of these organic or inorganic toxic substances may lead to emaciation, ill-thrift, and poor external aspect. The anti-nutritional factors and alkaloids of several plants, including pyrrolizidine alkaloids, among others, have also been associated with emaciation and/or poor general performance in sheep flocks. In this review, some of these disorders are discussed with an emphasis on clinical signs and lesions, relevant diagnostic aspects, and available therapeutic approaches. In most cases, demonstrating a history of exposure should be one of the most relevant aspects of the diagnostic approach, and removing the animals from the toxic source is the cornerstone of the majority of the treatment strategies.
感染性和寄生虫病原体常与绵羊的衰弱和消瘦状况有关。这些病原体的流行可能削弱了毒性因素在导致此类疾病方面的作用。此外，许多此类中毒情况经常会引发具有特定和特征性病变的急性临床疾病，因此与有毒物质的因果关系可能相对容易确立。然而，持续接触某些有机或无机有毒物质可能导致消瘦、生长不良和外观不佳。几种植物的抗营养因子和生物碱，包括吡咯里西啶生物碱等，也与羊群的消瘦和/或整体性能不佳有关。在本综述中，将讨论其中一些疾病，重点是临床症状和病变、相关诊断方面以及可用的治疗方法。在大多数情况下，证明接触史应是诊断方法中最相关的方面之一，将动物从有毒源中移出是大多数治疗策略的基石。
