Zühlke Alexandra, Gasik Michael, Shahramian Khalil, Närhi Timo, Bilotsky Yevgen, Kangasniemi Ilkka
School of Chemical Engineering, Aalto University Foundation, 00076 AALTO Espoo, Finland.
Department of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Turku, 20500 Turku, Finland.
Materials (Basel). 2021 Jan 19;14(2):455. doi: 10.3390/ma14020455.
Prevention of bacterial inflammation around dental implants (peri-implantitis) is one of the keys to success of the implantation and can be achieved by securing the gingival tissue-abutment interface preventing penetration of bacteria. Modern dental practice has adopted zirconia abutments in place of titanium, but the adhesion of gingival tissue to zirconia is inferior to titanium. The aim of this study was to assess and improve the adhesion of mucosal tissues to zirconia posts using sol-gel derived TiO coating following dynamic mechanical testing. The posts were cultivated with porcine bone-gingival tissue specimens in vitro for 7 and 14 days and then subjected to dynamic mechanical analysis simulating physiological loading at 1 Hz up to 50 μm amplitude. In parallel in silico analysis of stresses and strains have been made simulating "the worst case" when the fixture fails in osseointegration while the abutment still holds. Results show treatment of zirconia can lead to double interface stiffness (static shear stiffness values from 5-10 to 17-23 kPa and dynamic from 20-50 to 60-125 kPa), invariant viscostiffness (from 5-35 to 45-90 kPa·s) and material memory values (increased from 0.06-0.10 to 0.17-0.25), which is beneficial in preventing bacterial contamination in dental implants. This suggests TiO-coated zirconia abutments may have a significant clinical benefit for prevention of the bacterial contamination.
预防牙种植体周围的细菌性炎症(种植体周炎)是种植成功的关键之一,可通过确保牙龈组织与基台界面防止细菌侵入来实现。现代牙科实践已采用氧化锆基台取代钛基台,但牙龈组织与氧化锆的粘附性不如钛。本研究的目的是在动态力学测试后,使用溶胶-凝胶衍生的TiO涂层评估并改善粘膜组织与氧化锆桩的粘附性。将桩与猪骨-牙龈组织标本在体外培养7天和14天,然后进行动态力学分析,模拟1Hz频率、高达50μm振幅的生理负荷。同时,在计算机模拟分析中,模拟了种植体在骨整合失败而基台仍保持完好时的“最坏情况”下的应力和应变。结果表明,氧化锆的处理可导致双界面刚度(静态剪切刚度值从5-10kPa增加到17-23kPa,动态剪切刚度值从20-50kPa增加到60-125kPa)、不变的粘弹性刚度(从5-35kPa·s增加到45-90kPa·s)和材料记忆值(从0.06-0.10增加到0.17-0.25),这有利于防止牙种植体中的细菌污染。这表明TiO涂层的氧化锆基台可能对预防细菌污染具有显著的临床益处。