• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

内分泌干扰化学物质：当前的理解、新的测试策略和未来的研究需求。

Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs.

机构信息

Division of Paediatric Endocrinology and Diabetology, Paediatrics, Department of Mother and Child-AUSL of Reggio Emilia-IRCCS, 42123 Reggio Emilia, Italy.

INSERM UMR S1124, Université de Paris, 75006 Paris, France.

出版信息

Int J Mol Sci. 2021 Jan 19;22(2):933. doi: 10.3390/ijms22020933.

DOI:10.3390/ijms22020933
PMID:33477789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7832404/
Abstract

Endocrine disrupting chemicals (EDCs) are exogenous chemicals which can disrupt any action of the endocrine system, and are an important class of substances which play a role in the Developmental Origins of Health and Disease (DOHaD) [...].

摘要

内分泌干扰化学物质（EDCs）是外源性化学物质，可破坏内分泌系统的任何作用，是在健康与疾病的发育起源（DOHaD）中发挥作用的一类重要物质[... ]。

相似文献

1
Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs.内分泌干扰化学物质：当前的理解、新的测试策略和未来的研究需求。
Int J Mol Sci. 2021 Jan 19;22(2):933. doi: 10.3390/ijms22020933.
2
Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?与具有更高或相当内分泌活性的天然化合物相比，人类接触合成内分泌干扰化学物质（S-EDCs）的情况通常可忽略不计。如何评估S-EDCs的风险？
Toxicol Lett. 2020 Oct 1;331:259-264. doi: 10.1016/j.toxlet.2020.04.008. Epub 2020 Apr 30.
3
Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?与具有更高或相当内分泌活性的天然化合物相比，人类接触合成内分泌干扰化学品（S-EDCs）通常可以忽略不计。如何评估 S-EDCs 的风险？
Environ Toxicol Pharmacol. 2020 Aug;78:103396. doi: 10.1016/j.etap.2020.103396. Epub 2020 Apr 29.
4
Fifteen years after "Wingspread"--environmental endocrine disrupters and human and wildlife health: where we are today and where we need to go.《温斯普雷宣言》发表十五年后——环境内分泌干扰物与人类和野生动物健康：我们如今的状况以及我们的前进方向。
Toxicol Sci. 2008 Oct;105(2):235-59. doi: 10.1093/toxsci/kfn030. Epub 2008 Feb 16.
5
Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?与具有更高或相当内分泌活性的天然化合物相比，人类接触合成内分泌干扰化学物质（S-EDCs）的情况通常可忽略不计。如何评估S-EDCs的风险？
Toxicol In Vitro. 2020 Sep;67:104861. doi: 10.1016/j.tiv.2020.104861. Epub 2020 Apr 30.
6
Activation of steroid hormone receptors: Shed light on the in silico evaluation of endocrine disrupting chemicals.甾体激素受体的激活：为内分泌干扰物的计算评估提供新视角。
Sci Total Environ. 2018 Aug 1;631-632:27-39. doi: 10.1016/j.scitotenv.2018.03.003. Epub 2018 Mar 6.
7
General Challenges and Recommendations for the Water Quality Criteria of Endocrine Disrupting Chemicals (EDCs).内分泌干扰物（EDCs）水质基准的一般挑战和建议。
Bull Environ Contam Toxicol. 2022 Jun;108(6):995-1000. doi: 10.1007/s00128-022-03462-1. Epub 2022 Mar 23.
8
[Endocrine disruptors are a novel direction of endocrinologic scientific investigation].内分泌干扰物是内分泌科学研究的一个新方向。
Vestn Ross Akad Med Nauk. 2012(3):56-61.
9
Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?与具有更高或相当内分泌活性的天然化合物相比，人类接触合成内分泌干扰化学物质（S-EDCs）通常可以忽略不计。如何评估 S-EDCs 的风险？
Chem Biol Interact. 2020 Aug 1;326:109099. doi: 10.1016/j.cbi.2020.109099. Epub 2020 May 1.
10
The impact of endocrine disruptors on endocrine targets.内分泌干扰物对内分泌靶标的影响。
Horm Metab Res. 2010 Jul;42(8):543-52. doi: 10.1055/s-0030-1252034. Epub 2010 Apr 23.

引用本文的文献

1
Mitigating Dietary Bisphenol Exposure Through the Gut Microbiota: The Role of Next-Generation Probiotics in Bacterial Detoxification.通过肠道微生物群减轻饮食双酚 A 暴露：新一代益生菌在细菌解毒中的作用。
Nutrients. 2024 Oct 31;16(21):3757. doi: 10.3390/nu16213757.
2
Science evolves but outdated testing and static risk management in the US delay protection to human health.科学在不断发展，但美国过时的检测方法和静态风险管理延缓了对人类健康的保护。
Front Toxicol. 2024 Aug 13;6:1444024. doi: 10.3389/ftox.2024.1444024. eCollection 2024.
3
Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps.AOP-Wiki数据库的全面映射：识别生物学和疾病方面的差距。
Front Toxicol. 2024 Mar 8;6:1285768. doi: 10.3389/ftox.2024.1285768. eCollection 2024.
4
β-Cyclodextrin capped ZnS nanoparticles for CER-assisted colorimetric and spectrophotometric detection of Pb⁺, Cu⁺, and Hg⁺ in an aqueous solution.β-环糊精包覆的硫化锌纳米颗粒用于在水溶液中进行铈增强比色法和分光光度法检测Pb⁺、Cu⁺和Hg⁺
Heliyon. 2023 Nov 4;9(11):e21850. doi: 10.1016/j.heliyon.2023.e21850. eCollection 2023 Nov.
5
Effects of Endocrine-Disrupting Heavy Metals on Human Health.内分泌干扰性重金属对人体健康的影响。
Toxics. 2023 Mar 29;11(4):322. doi: 10.3390/toxics11040322.
6
Obesity III: Obesogen assays: Limitations, strengths, and new directions.肥胖症 III：肥胖基因检测：局限性、优势及新方向。
Biochem Pharmacol. 2022 May;199:115014. doi: 10.1016/j.bcp.2022.115014. Epub 2022 Apr 5.
7
Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities.基于证据的方法支持内分泌介导的不良结局途径的发展：挑战与机遇
Front Toxicol. 2021 Dec 21;3:787017. doi: 10.3389/ftox.2021.787017. eCollection 2021.
8
Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action.肥胖诱导物：它们的鉴定方法及作用的分子机制。
Front Endocrinol (Lausanne). 2021 Nov 25;12:780888. doi: 10.3389/fendo.2021.780888. eCollection 2021.
9
A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation.实用主义方法在不良结局路径开发与评估中的应用。
Toxicol Sci. 2021 Nov 24;184(2):183-190. doi: 10.1093/toxsci/kfab113.

本文引用的文献

1
Sex-biased impact of endocrine disrupting chemicals on behavioral development and vulnerability to disease: Of mice and children.内分泌干扰化学物质对行为发育和疾病易感性的性别差异影响：小鼠与儿童的情况
Neurosci Biobehav Rev. 2021 Feb;121:29-46. doi: 10.1016/j.neubiorev.2020.11.015. Epub 2020 Nov 25.
2
The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity.ENDpoiNTs 项目：与发育神经毒性相关的内分泌干扰物的新型测试策略。
Int J Mol Sci. 2020 Jun 1;21(11):3978. doi: 10.3390/ijms21113978.
3
Interactive Effects of Perinatal BPA or DES and Adult Testosterone and Estradiol Exposure on Adult Urethral Obstruction and Bladder, Kidney, and Prostate Pathology in Male Mice.围产期 BPA 或 DES 与成年睾酮和雌二醇暴露对雄性小鼠成年尿道梗阻及膀胱、肾脏和前列腺病理学的交互作用。
Int J Mol Sci. 2020 May 30;21(11):3902. doi: 10.3390/ijms21113902.
4
The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds.GOLIATH 项目：朝着国际协调一致的方法测试代谢干扰化合物迈进。
Int J Mol Sci. 2020 May 14;21(10):3480. doi: 10.3390/ijms21103480.
5
Integrated Approach to Evaluate the Association between Exposure to Pesticides and Idiopathic Premature Thelarche in Girls: The PEACH Project.综合评估暴露于农药与女童特发性性早熟关系的方法：PEACH 项目。
Int J Mol Sci. 2020 May 6;21(9):3282. doi: 10.3390/ijms21093282.
6
Effects of Prenatal Exposure to a Low-Dose of Bisphenol A on Sex Differences in Emotional Behavior and Central Alpha-Adrenergic Receptor Binding.产前低剂量双酚 A 暴露对情绪行为和中枢 α-肾上腺素能受体结合的性别差异的影响。
Int J Mol Sci. 2020 May 5;21(9):3269. doi: 10.3390/ijms21093269.
7
Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals-The FREIA Project.保护女性生殖健康免受内分泌干扰化学品的侵害——FREIA 项目。
Int J Mol Sci. 2020 May 1;21(9):3215. doi: 10.3390/ijms21093215.
8
Bisphenol a Exposure in Utero Disrupts Hypothalamic Gene Expression Particularly Genes Suspected in Autism Spectrum Disorders and Neuron and Hormone Signaling.胚胎暴露于双酚 A 会扰乱下丘脑基因表达，特别是那些疑似与自闭症谱系障碍以及神经元和激素信号有关的基因。
Int J Mol Sci. 2020 Apr 29;21(9):3129. doi: 10.3390/ijms21093129.
9
Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project.通过开发新的检测方法识别甲状腺激素系统干扰化学物质以消除化学测试方法中的关键差距——ATHENA 项目。
Int J Mol Sci. 2020 Apr 28;21(9):3123. doi: 10.3390/ijms21093123.
10
The EDCMET Project: Metabolic Effects of Endocrine Disruptors.EDCMET 项目：内分泌干扰物的代谢效应。
Int J Mol Sci. 2020 Apr 24;21(8):3021. doi: 10.3390/ijms21083021.