Department of Epidemiology and Tropical Medicine, Military Institute of Medicine, 128 Szaserów St., 04-141 Warsaw, Poland.
Department of Occupational, Metabolic and Internal Diseases, Institute of Maritime and Tropical Medicine, Medical University of Gdańsk, 9B Powstania Styczniowego St., 81-519 Gdynia, Poland.
Int J Environ Res Public Health. 2021 Jan 19;18(2):814. doi: 10.3390/ijerph18020814.
According to the World Health Organization 94% of global malaria cases and 94% of global malaria deaths have been reported from Africa. Unfortunately, it is difficult to determine the exact prevalence of disease in some African countries due to a large number of asymptomatic cases. The aim of this study was to assess the prevalence of malaria infections in seemingly healthy children living in the Central African Republic (CAR). CareStart Malaria HRP2 rapid diagnostic test (RDT) targeting was used to test a group of 500 asymptomatic children aged 1-15 years old (330 settled Bantu and 170 semi-nomadic BaAka Pygmies) inhabiting the villages in the Dzanga Sangha region (south-west CAR) in March 2020. In total, 32.4% of asymptomatic Bantu and 40.6% of asymptomatic Pygmy children had a positive result of malaria RDT. Our findings allowed us to demonstrate the high prevalence of asymptomatic malaria infections in south-west CAR. RDTs seem to be a useful tool for the detection of in areas with limited possibilities of using other diagnostic methods, such as light microscopy and molecular biology.
根据世界卫生组织的数据，94%的全球疟疾病例和 94%的全球疟疾死亡病例发生在非洲。不幸的是，由于大量无症状病例的存在，一些非洲国家的疾病确切流行率难以确定。本研究旨在评估中非共和国（CAR）看似健康的儿童中疟疾感染的流行率。使用 CareStart Malaria HRP2 快速诊断检测（RDT）针对 进行检测，共检测了 500 名年龄在 1-15 岁之间（330 名定居班图人和 170 名半游牧巴阿卡俾格米人）的无症状儿童，他们居住在 2020 年 3 月的桑加地区（CAR 西南部）的村庄中。无症状班图儿童中有 32.4%，无症状俾格米儿童中有 40.6%的人疟疾 RDT 检测结果呈阳性。我们的研究结果表明，CAR 西南部无症状疟疾感染的高流行率。RDT 似乎是在其他诊断方法（如显微镜检查和分子生物学）应用受限的地区检测 的有用工具。
