Ismail Adel Aa
Retired Consultant in Clinical Biochemistry and Chemical Endocrinology, West Yorkshire, UK.
Ann Clin Biochem. 2022 Jan;59(1):59-64. doi: 10.1177/0004563221992390. Epub 2021 Feb 10.
The ongoing coronavirus (covid-19) pandemic highlights the need for global scientific cooperation to advance our understanding of the immunological, molecular and biochemical mechanisms causing infection by this virus. Better understanding of key processes has allowed the development of vaccines in record time, and of agents with the potential to treat and neutralize current and future coronavirus outbreaks. To date, clinically effective agents for prevention and treatment of covid-19 infections are limited. This review provides a brief synopsis regarding the molecular biology, pathology and laboratory tests commonly used in the diagnosis and prognosis of covid-19, as well as the development of vaccines and therapeutic strategies to manage its current and future mutations.
持续的冠状病毒（COVID-19）大流行凸显了全球科学合作的必要性，以增进我们对该病毒感染所涉及的免疫、分子和生化机制的理解。对关键过程的更好理解使得能够在创纪录的时间内研发出疫苗，以及开发出有可能治疗和中和当前及未来冠状病毒爆发的药物。迄今为止，用于预防和治疗COVID-19感染的临床有效药物有限。本综述简要概述了COVID-19诊断和预后中常用的分子生物学、病理学及实验室检测，以及疫苗的研发和应对其当前及未来变异的治疗策略。
