抗生素治疗扁桃体周围感染：克林霉素与青霉素。
Antibiotics in treatment of peritonsillar infection: clindamycin versus penicillin.
机构信息
Department of Otorhinolaryngology Head and Neck Surgery, Södra Älvsborg Hospital, Borås, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Sweden.
Department of Infectious Diseases, Södra Älvsborg Hospital, Borås, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Sweden.
出版信息
J Laryngol Otol. 2021 Jan;135(1):64-69. doi: 10.1017/S002221512100013X. Epub 2021 Jan 22.
OBJECTIVE
This study aimed to compare antibiotic treatment with clindamycin versus penicillin V or G in terms of time to recovery and recurrence in patients with peritonsillar infection, including both peritonsillar cellulitis and peritonsillar abscess.
METHOD
This retrospective cohort study examined the records of 296 patients diagnosed with peritonsillar infection. Based on the ENT doctor's choice of antibiotics, patients were divided into clindamycin and penicillin groups.
RESULTS
Mean number of days in follow up was 3.5 days in the clindamycin group and 3.4 days in the penicillin group. The recurrence rate within 2 months was 7 per cent in the clindamycin group and 4 per cent in the penicillin group.
CONCLUSION
This study found no significant differences in either recovery or recurrence between the groups. This supports the use of penicillin as a first-line treatment, considering the greater frequency of adverse effects of clindamycin shown in previous studies, as well as its profound collateral damage on the intestinal microbiota, resulting in antibiotic resistance.
目的
本研究旨在比较克林霉素与青霉素 V 或 G 在治疗扁桃体周围感染（包括扁桃体周围蜂窝织炎和扁桃体周围脓肿）患者的恢复时间和复发率方面的差异。
方法
本回顾性队列研究检查了 296 例诊断为扁桃体周围感染患者的记录。根据耳鼻喉科医生选择的抗生素，患者被分为克林霉素组和青霉素组。
结果
克林霉素组的平均随访天数为 3.5 天，青霉素组为 3.4 天。克林霉素组的 2 个月内复发率为 7%，青霉素组为 4%。
结论
本研究发现两组在恢复或复发方面均无显著差异。鉴于克林霉素在先前的研究中显示出更高的不良反应频率，以及它对肠道微生物群造成的深远的附带损害，导致抗生素耐药性，因此支持将青霉素作为一线治疗药物。
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