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冲击波的生物学效应:狗体内冲击波导致的肾损伤——剂量依赖性

Biological effects of shock waves: kidney damage by shock waves in dogs--dose dependence.

作者信息

Delius M, Enders G, Xuan Z R, Liebich H G, Brendel W

机构信息

Institute for Surgical Research, University of Munich, Federal Republic of Germany.

出版信息

Ultrasound Med Biol. 1988;14(2):117-22. doi: 10.1016/0301-5629(88)90178-0.

DOI:10.1016/0301-5629(88)90178-0
PMID:3347964
Abstract

The effect of shock waves on normal canine kidneys was examined in three groups of dogs whose right kidneys were exposed to 500, 1500, or 3000 shock waves. Autopsy was performed 24-30 h later. The kidneys were enlarged with haemorrhages in the outer and inner renal capsule and intraparenchymally. Macroscopically intraparenchymal haemorrhages were restricted to the high pressure field of the shock wave and consisted of haematomas up to 18 mm diameter (most frequently 6 mm or less) and diffuse haemorrhages. Histologically, haemorrhages were shown to originate from interlobular and arcuate veins. Venous thrombosis, tubular dilatation, and diffuse interstitial haemorrhage occurred in the same area. The number of haematomas was larger, and diffuse haemorrhages were more extended after the application of 1500 and 3000 than after 500 shock waves. No difference was seen between 1500 and 3000 shock waves.

摘要

在三组犬中研究了冲击波对正常犬肾的影响,这三组犬的右肾分别接受500次、1500次或3000次冲击波。24 - 30小时后进行尸检。肾脏肿大,肾外膜和肾内膜以及实质内有出血。宏观上,实质内出血局限于冲击波的高压区域,由直径达18毫米(最常见为6毫米或更小)的血肿和弥漫性出血组成。组织学上,出血显示起源于小叶间静脉和弓状静脉。静脉血栓形成、肾小管扩张和弥漫性间质出血发生在同一区域。与500次冲击波后相比,应用1500次和3000次冲击波后血肿数量更多,弥漫性出血范围更广。1500次和3000次冲击波之间未见差异。

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Ultrasound Med Biol. 1988;14(2):117-22. doi: 10.1016/0301-5629(88)90178-0.
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