Laboratoire des Sciences Analytiques, Bioanalytiques et Miniaturisation-UMR Chimie Biologie Innovation 8231, ESPCI Paris, CNRS, PSL University, Paris, 75005, France.
Sorbonne Université, Paris, 75005, France.
J Sep Sci. 2021 Apr;44(8):1727-1751. doi: 10.1002/jssc.202001223. Epub 2021 Feb 7.
Molecularly imprinted polymers are highly selective and cost-effective materials, which have attracted significant interest in various areas such as sample pretreatment and chromatographic and electrophoretic separations. This review aims to present the state of the art concerning the miniaturization of these materials in order to meet the societal demand for reliable, fast, cheap, and solvent/sample saving analyses. The polymerization route specificities for the production of miniaturized molecularly imprinted polymers in capillaries or chip channels, such as open tubular, packed particles, magnetic nanoparticles, and in situ imprinted monoliths, are investigated. Their performances as selective supports in solid phase extraction and as stationary phases in electrochromatography and liquid chromatography, as well as their possible perspectives are discussed.
分子印迹聚合物是一种高选择性且具有成本效益的材料，已在样品预处理以及色谱和电泳分离等各个领域引起了广泛关注。本综述旨在介绍这些材料的小型化现状，以满足对可靠、快速、廉价和节省溶剂/样品分析的社会需求。本研究考察了在毛细管或芯片通道中制备小型化分子印迹聚合物的聚合途径特异性，如开管、填充颗粒、磁性纳米颗粒和原位印迹整体柱。讨论了它们作为固相萃取中的选择性载体以及电色谱和液相色谱中的固定相的性能及其可能的前景。
