对映选择性铱催化的外消旋支链烷基取代烯丙基乙酸酯与丙二酸酯的烯丙基烷基化反应。
Enantioselective Iridium-Catalyzed Allylic Alkylation of Racemic Branched Alkyl-Substituted Allylic Acetates with Malonates.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Org Lett. 2021 Feb 5;23(3):1086-1089. doi: 10.1021/acs.orglett.0c04309. Epub 2021 Jan 22.
The regio- and enantioselective allylic substitution of branched alkyl-substituted allylic acetates employing malonates has been achieved through a process that calls for Krische's π-allyliridium ,-benzoate catalyst. The protocol reported herein can be applied to a diverse set of branched alkyl substrates that are generally not well tolerated in the other two types of Ir-catalyzed allylation.
Krische 的 π-烯丙基铱、-苯甲酸酯催化剂实现了通过支链烷基取代烯丙基乙酸酯与丙二酸酯的区域和对映选择性烯丙基取代反应。本文报道的方案可应用于一组广泛的支链烷基底物，这些底物在其他两种 Ir 催化的烯丙基化反应中通常不能很好地耐受。
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