Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences (Wuhan), 388 Lumo Road, Wuhan 430074, PR China.
Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences (Wuhan), 388 Lumo Road, Wuhan 430074, PR China.
Food Chem. 2021 Jun 15;347:129002. doi: 10.1016/j.foodchem.2021.129002. Epub 2021 Jan 9.
A robust magnetic solid-phase extraction (MSPE) method based on magnetic covalent organic framework (MCOF) coupled with high-performance liquid chromatography (HPLC)-ultraviolet (UV)/mass spectrometry (MS) was proposed for the determination of trace diclofenac sodium (DS) in milk. The prepared MCOF exhibited high extraction efficiency, which can be attributed to its high specific surface area as well as strong π-π and hydrophobic interactions between MCOF and DS. In addition, the potential influencing factors, including sample volume, adsorbent dosage, extraction time, and elution parameters, were fully estimated. The experimental results demonstrated that the established method was sensitive for the quantification of DS with high accuracy. Remarkably, the detection limit of DS was found to be 10 ng/kg under the optimal conditions. More impressively, the developed method was successfully applied to monitor trace DS in milk, demonstrating its outstanding durability and practical potential as an appealing method to regular monitor trace pharmaceutical contaminants in real food samples.
基于磁性共价有机框架（MCOF）结合高效液相色谱（HPLC）-紫外（UV）/质谱（MS），提出了一种用于检测牛奶中痕量双氯芬酸钠（DS）的强大磁性固相萃取（MSPE）方法。所制备的 MCOF 表现出高的萃取效率，这归因于其高比表面积以及 MCOF 和 DS 之间的强 π-π 和疏水性相互作用。此外，还充分评估了包括样品体积、吸附剂用量、萃取时间和洗脱参数在内的潜在影响因素。实验结果表明，该方法对 DS 的定量具有很高的灵敏度和准确性。值得注意的是，在最佳条件下，DS 的检测限被发现低至 10ng/kg。更令人印象深刻的是，该方法成功地应用于监测牛奶中的痕量 DS，表明其作为一种有吸引力的方法，在实际食品样品中常规监测痕量药物污染物方面具有出色的耐用性和实用潜力。
