Tissue Engineering & Additive Manufacturing (TEAM) Lab, Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), ABCDE Innovation Centre, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu 613401, India.
Tissue Engineering & Additive Manufacturing (TEAM) Lab, Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), ABCDE Innovation Centre, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu 613401, India.
Carbohydr Polym. 2021 Mar 15;256:117561. doi: 10.1016/j.carbpol.2020.117561. Epub 2020 Dec 28.
Carboxymethyl cellulose (CMC) is a water-soluble derivative of cellulose and a major type of cellulose ether prepared by the chemical attack of alkylating reagents on the activated non-crystalline regions of cellulose. It is the first FDA approved cellulose derivative which can be targeted for desired chemical modifications. In this review, the properties along with current advances in the physical and chemical modifications of CMC are discussed. Further, CMC and modified CMC could be engineered to fabricate scaffolds for tissue engineering applications. In recent times, CMC and its derivatives have been developed as smart bioinks for 3D bioprinting applications. From these perspectives, the applications of CMC in tissue engineering and current knowledge on peculiar features of CMC in 3D and 4D bioprinting applications are elaborated in detail. Lastly, future perspectives of CMC for wider applications in tissue engineering and 3D/4D bioprinting are highlighted.
羧甲基纤维素（CMC）是纤维素的水溶性衍生物，也是通过烷基化试剂对纤维素的非晶区进行化学攻击而制备的主要纤维素醚之一。它是第一个获得美国食品和药物管理局（FDA）批准的可进行所需化学修饰的纤维素衍生物。在本综述中，讨论了 CMC 的性质以及其物理和化学修饰方面的最新进展。此外，还可以对 CMC 和改性 CMC 进行工程设计，以制造用于组织工程应用的支架。在最近的时期，CMC 及其衍生物已被开发为用于 3D 生物打印应用的智能生物墨水。从这些角度来看，详细阐述了 CMC 在组织工程中的应用以及 CMC 在 3D 和 4D 生物打印应用中的特殊特性的现有知识。最后，强调了 CMC 在组织工程和 3D/4D 生物打印中的更广泛应用的未来前景。
