School of Light Industry and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
School of Light Industry and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Carbohydr Polym. 2021 Mar 15;256:117590. doi: 10.1016/j.carbpol.2020.117590. Epub 2021 Jan 4.
Hydrogels, being highly biocompatible and adaptable with biological tissues, have shown great usability in biomedical applications. In this research, a novel hydrogel film developed from carboxymethyl chitosan (CMCS) loaded with waterborne polyurethane-gelatin hydrolysate was synthesized via aqueous emulsion copolymerization. The synthesized hydrogel film was characterized using mechanical strength tests, FTIR, XPS, SEM, AFM, and various other analysis technologies. The results demonstrated that the hydrogel film exhibited good thermal stability, swelling behavior, as well as controllable biodegradability. Specifically, when the CMCS content was loaded at 6 %, the maximum tensile strength and elongation at the break of the hydrogel film were reached 31.69 MPa and 447.187, respectively. The disk diffusion tests indicated that the hydrogel film presented significant antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). These results indicate that hydrogel films with high mechanical strength and high antibacterial activity could be used for wound dressing applications.
水凝胶具有高度的生物相容性和对生物组织的适应性，在生物医学应用中显示出了巨大的可用性。在这项研究中，通过乳液共聚合成了一种由载有水溶性聚氨酯-明胶水解物的羧甲基壳聚糖（CMCS）制成的新型水凝胶膜。通过机械强度测试、FTIR、XPS、SEM、AFM 等各种分析技术对合成的水凝胶膜进行了表征。结果表明，水凝胶膜表现出良好的热稳定性、溶胀行为和可控的生物降解性。具体来说，当 CMCS 含量负载为 6%时，水凝胶膜的最大拉伸强度和断裂伸长率分别达到 31.69 MPa 和 447.187。圆盘扩散试验表明，水凝胶膜对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）具有显著的抗菌活性。这些结果表明，具有高机械强度和高抗菌活性的水凝胶膜可用于伤口敷料应用。
