School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210096, China.
Mol Biol Rep. 2021 Feb;48(2):1763-1771. doi: 10.1007/s11033-021-06148-9. Epub 2021 Jan 22.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to the outbreak of coronavirus disease 2019 (COVID-19), a worldwide epidemic disease affecting increasing number of patients. Although the virus primarily targets respiratory system, cardiovascular involvement has been reported in accumulating studies. In this review, we first describe the cardiac disorders in human with various types of CoV infection, and in animals infected with coronavirus. Particularly, we will focus on the association of cardiovascular disorders upon SARS-CoV-2 infection, and prognostic cardiac biomarkers in COVID-19. Besides, we will discuss the possible mechanisms underlying cardiac injury resulted from SARS-CoV-2 infection including direct myocardial injury caused by viral infection, reduced level of ACE2, and inflammatory response during infection. Improved understandings of cardiac disorders associated with COVID-19 might predict clinical outcome and provide insights into more rational treatment responses in clinical practice.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）导致了 2019 年冠状病毒病（COVID-19）的爆发，这是一种全球性的传染病，影响了越来越多的患者。尽管该病毒主要针对呼吸系统，但在越来越多的研究中已经报道了心血管系统的受累。在这篇综述中，我们首先描述了各种类型的 CoV 感染以及感染冠状病毒的动物中的心脏疾病。特别地，我们将重点关注 SARS-CoV-2 感染时心血管疾病的关联以及 COVID-19 中的预后性心脏生物标志物。此外，我们还将讨论 SARS-CoV-2 感染导致心肌损伤的可能机制，包括病毒感染引起的直接心肌损伤、ACE2 水平降低以及感染期间的炎症反应。更好地了解与 COVID-19 相关的心脏疾病可能有助于预测临床结果，并为临床实践中更合理的治疗反应提供见解。
