骨生物学与 COVID-19 感染：ACE2 是潜在影响因素吗？
Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?
机构信息
Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.
ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
出版信息
Med Hypotheses. 2020 Nov;144:110178. doi: 10.1016/j.mehy.2020.110178. Epub 2020 Aug 10.
The outbreak of coronavirus disease 2019 (COVID-19) has posed a severe threat to global health management system since it has been detected in the human body. This pandemic was prompted by severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) and rapidly developed into a public emergency with an alarming increase in cases and deaths. The increasing explorations to SARS-CoV-2 infection guide us to consider whether bone lesion is followed by this pathologic process. We especially focus on the underlying pathobiology that SARS-CoV-2 possibly mediated in bone remodeling and analyze the association of bone destruction with ACE2 in COVID-19 incidence, for preferable understanding the pathogenesis and providing necessary clinical management in orthopedics.
2019 年冠状病毒病（COVID-19）的爆发自人体检测到以来，对全球卫生管理系统构成了严重威胁。这种大流行是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引发的，并迅速发展成为公共卫生紧急事件，病例和死亡人数令人震惊地增加。对 SARS-CoV-2 感染的不断探索促使我们考虑是否存在骨病变伴随这一病理过程。我们特别关注 SARS-CoV-2 可能在骨重塑中介导的潜在病理生物学，并分析 COVID-19 发病过程中骨破坏与 ACE2 的相关性，以便更好地了解发病机制，并为骨科提供必要的临床管理。
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