干细胞疗法治疗急性心肌梗死：新时代？
Stem cells therapy in acute myocardial infarction: a new era?
机构信息
Department of Internal Medicine, University of Genoa, Genoa, Italy.
Tel Aviv University, Tel Aviv, Israel.
出版信息
Clin Exp Med. 2021 May;21(2):231-237. doi: 10.1007/s10238-021-00682-3. Epub 2021 Jan 23.
Abstract
Stem cells transplantation after acute myocardial infarction (AMI) has been claimed to restore cardiac function. However, this therapy is still restricted to experimental studies and clinical trials. Early un-blinded studies suggested a benefit from stem cell therapy following AMI. More recent blinded randomized trials have produced mixed results and, notably, the last largest pan-European clinical trial showed the inconclusive results. Furthermore, mechanisms of potential benefit remain uncertain. This review analytically evaluates 34 blinded and un-blinded clinical trials comprising 3142 patients and is aimed to: (1) identify the pros and cons of stem cell therapy up to a 6-month follow-up after AMI comparing benefit or no effectiveness reported in clinical trials; (2) provide useful information for planning future clinical programs of cardiac stem cell therapy.
摘要
急性心肌梗死（AMI）后进行干细胞移植据称可以恢复心脏功能。然而，这种治疗方法仍然局限于实验研究和临床试验。早期非盲研究表明 AMI 后干细胞治疗有益。最近的盲法随机试验得出了混合的结果，值得注意的是，最后一项最大的泛欧临床研究显示出不确定的结果。此外，潜在益处的机制仍不确定。本综述分析评估了 34 项盲法和非盲法临床试验，共纳入 3142 例患者，旨在：（1）在 AMI 后 6 个月的随访中，确定临床试验报告的获益或无效果，从而分析干细胞治疗的优缺点；（2）为规划未来的心脏干细胞治疗临床项目提供有用的信息。
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