Department of Microbiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK; South Yorkshire Regional Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
South Yorkshire Regional Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
J Hosp Infect. 2021 Apr;110:103-107. doi: 10.1016/j.jhin.2021.01.006. Epub 2021 Jan 20.
It can be a diagnostic challenge to identify patients with coronavirus disease 2019 in whom antibiotics can be safely withheld. This study evaluated the effectiveness of a guideline implemented at Sheffield Teaching Hospitals NHS Foundation Trust that recommends withholding antibiotics in patients with low serum procalcitonin (PCT), defined as ≤0.25 ng/mL. Results showed reduced antibiotic consumption in patients with PCT ≤0.25 ng/mL with no increase in mortality, alongside a reduction in subsequent carbapenem prescriptions during admission. The results support the effectiveness of this guideline, and further research is recommended to identify the optimal cut-off value for PCT in this setting.
在确定哪些新冠肺炎患者可以安全停用抗生素时，这可能是一个诊断上的挑战。本研究评估了谢菲尔德教学医院 NHS 基金会信托实施的一项指南的有效性，该指南建议将血清降钙素原 (PCT) 水平低的患者（定义为≤0.25ng/mL）的抗生素停用。结果表明，PCT ≤0.25ng/mL 的患者的抗生素使用量减少，而死亡率没有增加，同时入院期间碳青霉烯类药物的后续处方减少。结果支持该指南的有效性，建议进一步研究以确定该情况下 PCT 的最佳截断值。
