Salem Hesham, Abo Elsoud Fatma A, Heshmat Dina, Magdy Ahmed
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, New Minia, Egypt.
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, New Minia, Egypt.
Spectrochim Acta A Mol Biomol Spectrosc. 2021 Apr 15;251:119428. doi: 10.1016/j.saa.2021.119428. Epub 2021 Jan 8.
A exceedingly touchy resonance Rayleigh scattering (RRS) strategy for the assurance of nilotinib (NILO) was introduced. In the pH 3.4 acetate buffer solution, NILO reacted with erythrosine B to produce an ion-association complex, which increased the RRS intensity of the studied system. The enhanced RRS intensity (ΔI) was linearly proportional to the concentration of NILO, the linear range of the method was 0.1-1.0 µg/mL and the detection limit (DL) was 0.025 µg/mL. In like manner, this test was connected to distinguish the concentration of NILO in capsules and human plasma with palatable comes about.
介绍了一种用于测定尼洛替尼（NILO）的极其灵敏的共振瑞利散射（RRS）策略。在pH 3.4的醋酸盐缓冲溶液中，NILO与赤藓红B反应生成离子缔合络合物，这增加了所研究体系的RRS强度。增强的RRS强度（ΔI）与NILO的浓度呈线性比例关系，该方法的线性范围为0.1 - 1.0μg/mL，检测限（DL）为0.025μg/mL。同样，该试验用于测定胶囊和人血浆中NILO的浓度，结果良好。
