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老年人骨质疏松症。

Osteoporosis in older adults.

机构信息

Service de Rhumatologie, CHU Angers, 4, rue Larrey, 49933 Angers, France; Groupe d'étude sur le remodelage osseux et les biomatériaux, CHU Angers, 4, rue Larrey, 49933 Angers, France; Faculté de Santé, Université d'Angers, Angers, France.

Faculté de Santé, Université d'Angers, Angers, France; Département de gériatrie et Centre mémoire ressources recherche, Centre de recherche sur l'autonomie et la longévité, Centre Hospitalier Universitaire, UPRES EA 4638, Université d'Angers, UNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada.

出版信息

Joint Bone Spine. 2021 May;88(3):105135. doi: 10.1016/j.jbspin.2021.105135. Epub 2021 Jan 21.

Abstract

The incidence of fragility fractures increases progressively with advance in age after 50 years, and the phenomenon of population ageing will lead to an increased proportion of the world population having osteoporosis and fractures. The consequences of fractures are more serious in older adults: all low-trauma fractures were associated with increased mortality risk and the risk of a second major osteoporotic fracture after a first one also increased with advance in age. Along with the decrease in bone mineral density, falls play an essential role in the occurrence of fragility fractures in older adults, and the assessment of the risk of falling is part of the fracture risk assessment. Despite advances in the diagnosis of osteoporosis, the assessment of fracture risk, and a wide range of effective anti-osteoporosis medications, with parenteral route which can improve observance, many data indicate that the therapeutic care gap is particularly wide in the elderly in whom the importance and impact of a treatment are high and even more in those living in institutions.

摘要

脆性骨折的发生率在 50 岁以后随年龄增长逐渐增加,人口老龄化现象将导致世界上患有骨质疏松症和骨折的人口比例增加。骨折的后果在老年人中更为严重:所有低创伤性骨折都与死亡率增加相关,第一次骨折后发生第二次主要骨质疏松性骨折的风险也随年龄增长而增加。随着骨密度的降低,跌倒在老年人脆性骨折的发生中起着至关重要的作用,跌倒风险评估是骨折风险评估的一部分。尽管骨质疏松症的诊断、骨折风险评估以及广泛的有效抗骨质疏松症药物有所进展,且可改善用药依从性的注射途径,但许多数据表明,在老年人中,治疗差距特别大,他们的治疗的重要性和影响都很高,在那些居住在机构中的老年人中更是如此。

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