迟缓发酵菌2对抗菌药物的体外敏感性
Susceptibility of dysgonic fermenter 2 to antimicrobial agents in vitro.
作者信息
Verghese A, Hamati F, Berk S, Franzus B, Berk S, Smith J K
机构信息
Department of Medicine, Veterans Administration Medical Center, Johnson City, Tennessee.
出版信息
Antimicrob Agents Chemother. 1988 Jan;32(1):78-80. doi: 10.1128/AAC.32.1.78.
Abstract
Dysgonic fermenter 2 (DF-2) is a fastidious, gram-negative organism well recognized as a cause of fulminant septicemia in patients without spleens or patients with alcoholic cirrhosis. In vitro antibiotic susceptibility testing of eight strains with a Schaedler broth dilution technique revealed DF-2 to be susceptible to all of the antibiotics tested except aztreonam. Previous reports that DF-2 is aminoglycoside resistant were based on disk diffusion or agar dilution assays that may be less reliable given the slow growth of the organism and its requirement for CO2 incubation. Penicillin is commonly used as prophylaxis after dog bites and has excellent activity against DF-2.
摘要
迟缓发酵菌2（DF-2）是一种苛求的革兰氏阴性菌，是无脾患者或酒精性肝硬化患者暴发性败血症的公认病因。采用舍德勒肉汤稀释技术对8株菌株进行体外抗生素敏感性试验，结果显示DF-2对除氨曲南外的所有测试抗生素敏感。先前关于DF-2对氨基糖苷类耐药的报道是基于纸片扩散法或琼脂稀释法，鉴于该菌生长缓慢且需要二氧化碳培养，这些方法可能不太可靠。青霉素常用于狗咬伤后的预防，对DF-2有很好的活性。
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