Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, 80309-0347, USA.
J Mol Evol. 2021 Feb;89(1-2):45-49. doi: 10.1007/s00239-020-09984-8. Epub 2021 Jan 24.
The Standard Genetic Code (SGC) exists in every known organism on Earth. SGC evolution via early unique codon assignment, then later wobble, yields coding resembling the near-universal code. Below, later wobble is shown to also create an optimal route to accurate codon assignment. Time of optimal codon assignment matches the previously defined mean time for ordered coding, exhibiting ≥ 90% of SGC order. Accurate evolution is also accessible, sufficiently frequent to appear in populations of 10 to 10 codes. SGC-like coding capacity, code order, and accurate assignments therefore arise together, in one attainable evolutionary intermediate. Examples, which plausibly resemble coding at evolutionary domain separation, are characterized.
标准遗传密码（SGC）存在于地球上所有已知的生物体中。SGC 通过早期独特的密码子分配，然后是后期摆动，产生类似于近乎通用的密码子的编码。下文显示，后期摆动也创造了一种准确密码子分配的最佳途径。最佳密码子分配的时间与之前定义的有序编码的平均时间相匹配，表现出≥90%的 SGC 顺序。准确的进化也是可实现的，其在 10 到 10 个代码的种群中出现的频率足够高。因此，SGC 样的编码能力、代码顺序和准确的分配一起出现在一个可实现的进化中间状态中。对类似的编码进行了特征分析，这些编码可能与进化领域的分离有关。
