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渐强的胜任编码(c3)包含标准遗传密码。

A crescendo of competent coding (c3) contains the Standard Genetic Code.

机构信息

Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA

出版信息

RNA. 2022 Oct;28(10):1337-1347. doi: 10.1261/rna.079275.122. Epub 2022 Jul 22.

Abstract

The Standard Genetic Code (SGC) can arise by fusion of partial codes evolved in different individuals, perhaps for differing prior tasks. Such code fragments can be unified into an SGC after later evolution of accurate third-position Crick wobble. Late wobble advent fills in the coding table, leaving only later development of translational initiation and termination to reach the SGC in separated domains of life. This code fusion mechanism is computationally implemented here. Late Crick wobble after C3 fusion (c3-lCw) is tested for its ability to evolve the SGC. Compared with previously studied isolated coding tables, or with increasing numbers of parallel, but nonfusing codes, c3-lCw reaches the SGC sooner, is successful in a smaller population, and presents accurate and complete codes more frequently. Notably, a long crescendo of SGC-like codes is exposed for selection of superior translation. c3-lCw also effectively suppresses varied disordered assignments, thus converging on a unified code. Such merged codes closely approach the SGC, making its selection plausible. For example: Under routine conditions, ≈1 of 22 c3-lCw environments evolves codes with ≥20 assignments and ≤3 differences from the SGC, notably including codes identical to the Standard Genetic Code.

摘要

标准遗传密码(SGC)可以通过在不同个体中进化的部分代码融合而产生,这些代码可能具有不同的先前任务。这样的代码片段可以在后来的精确第三位置克里克摆动进化后统一为 SGC。晚期摆动的出现填补了编码表,只留下后来的翻译起始和终止的发展,以达到生命分离领域的 SGC。这里计算实现了这种代码融合机制。对 C3 融合后的晚期克里克摆动(c3-lCw)进行测试,以评估其进化 SGC 的能力。与之前研究的孤立编码表相比,或者与越来越多的并行但不融合的代码相比,c3-lCw 更快地达到 SGC,在较小的种群中取得成功,并更频繁地呈现准确和完整的代码。值得注意的是,SGC 样代码的长渐强揭示了优越翻译的选择。c3-lCw 还有效地抑制了各种无序分配,从而收敛到统一的代码。这种合并的代码非常接近 SGC,使其选择成为可能。例如:在常规条件下,在 22 个 c3-lCw 环境中,约有 1 个环境进化出具有 20 个以上分配且与 SGC 差异不超过 3 的代码,其中包括与标准遗传密码完全相同的代码。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8f/9479743/3a57b4d0206c/1337f01.jpg

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