持续性心房颤动患者 sST2 和半乳糖凝集素-3 基因分型。
sST2 and Galectin-3 genotyping in patients with persistent atrial fibrillation.
机构信息
Clinical Analyses Department, Universitary Hospital of Burgos, Burgos, Spain.
Cardiology Department, Universitary Hospital of Burgos, Avda. Islas Baleares, 3. 09006, Burgos, Spain.
出版信息
Mol Biol Rep. 2021 Feb;48(2):1601-1606. doi: 10.1007/s11033-021-06150-1. Epub 2021 Jan 23.
Genotyping of ST2 and galectin-3 in atrial fibrillation (AF) is not well analyzed. The aim of our study was to analyze the possible relationship between levels of sST2 and galectin-3 and three polymorphisms in patients with AF. We included 125 patients with persistent AF undergoing electric cardioversion. We analyzed sST2 and galectin-3 levels and three polymorphisms in peripheral blood samples. Rs2274273 was significantly related with levels of galectin-3. Rs1558648 was associated with levels of sST2 but rs13019803 were not. None of the polymorphisms were connected to the variation of biomarkers levels during the follow up. We found a relationship between rs2274273 and galectin-3 levels and rs1558648 and sST2 levels in patients with AF.
ST2 和半乳糖凝集素-3 的基因分型在心房颤动 (AF) 中分析得还不够完善。我们的研究目的是分析 AF 患者中 sST2 和半乳糖凝集素-3 水平与三种基因多态性之间的可能关系。我们纳入了 125 例接受电复律的持续性 AF 患者。我们分析了外周血样本中的 sST2 和半乳糖凝集素-3 水平和三种基因多态性。rs2274273 与半乳糖凝集素-3 水平显著相关。rs1558648 与 sST2 水平相关，但 rs13019803 不相关。在随访期间，没有任何多态性与生物标志物水平的变化有关。我们发现 AF 患者中 rs2274273 与半乳糖凝集素-3 水平之间以及 rs1558648 与 sST2 水平之间存在关系。
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