Team DYSAD, Dept2, Institute for Advanced Biosciences, Centre de Recherche Université Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Grenoble, France.
Small GTPases. 2021 Sep-Nov;12(5-6):429-439. doi: 10.1080/21541248.2021.1877081. Epub 2021 Jan 25.
Cell invasion is associated with numerous patho-physiologic states including cell development and metastatic dissemination. This process couples the activation of cell motility with the capacity to degrade the extracellular matrix, thereby permitting cells to pass through basal membranes. Invasion is sustained by the actions of invadosomes, an ensemble of subcellular structures with high functional homology. Invadosomes are 3D acto-adhesive structures that can also mediate local extracellular matrix degradation through the controlled delivery of proteases. Intracellular RHO GTPases play a central role in the regulation of invadosomes where their complex interplay regulates multiple invadosome functions. This review aims to provide an overview of the synergistic activities of the small GTPases in invadosome biology. This broad-based review also reinforces the importance of the spatiotemporal regulation of small GTPases and the impact of this process on invadosome dynamics.
细胞侵袭与许多病理生理状态相关，包括细胞发育和转移扩散。这一过程将细胞运动性的激活与降解细胞外基质的能力联系起来，从而使细胞能够穿透基底膜。侵袭是由侵袭小体的作用维持的，侵袭小体是一组具有高度功能同源性的亚细胞结构。侵袭小体是三维的肌动蛋白黏附结构，也可以通过蛋白酶的受控释放来介导局部细胞外基质的降解。细胞内的 RHO GTPases 在侵袭小体的调节中起着核心作用，它们的复杂相互作用调节着侵袭小体的多种功能。这篇综述旨在概述小 GTPases 在侵袭小体生物学中的协同作用。这篇基础广泛的综述还强调了小 GTPases 的时空调节的重要性及其对侵袭小体动力学的影响。
