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Targeting ubiquitin-specific protease-7 in plasmacytoid dendritic cells triggers anti-myeloma immunity.

作者信息

Ray Arghya, Du Ting, Song Yan, Buhrlage Sara J, Chauhan Dharminder, Anderson Kenneth C

机构信息

The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

出版信息

Leukemia. 2021 Aug;35(8):2435-2438. doi: 10.1038/s41375-021-01129-0. Epub 2021 Jan 24.

DOI:10.1038/s41375-021-01129-0
PMID:33487632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8302665/
Abstract
摘要

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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.选择性 USP7 抑制通过 p53 依赖性机制引发癌细胞杀伤。
Sci Rep. 2020 Mar 24;10(1):5324. doi: 10.1038/s41598-020-62076-x.
2
Inhibition of Nr4a Receptors Enhances Antitumor Immunity by Breaking Treg-Mediated Immune Tolerance.抑制 Nr4a 受体通过打破 Treg 介导的免疫耐受增强抗肿瘤免疫。
Cancer Res. 2018 Jun 1;78(11):3027-3040. doi: 10.1158/0008-5472.CAN-17-3102. Epub 2018 Mar 20.
3
Restoring Natural Killer Cell Immunity against Multiple Myeloma in the Era of New Drugs.
在新药时代恢复自然杀伤细胞对多发性骨髓瘤的免疫作用
Front Immunol. 2017 Nov 7;8:1444. doi: 10.3389/fimmu.2017.01444. eCollection 2017.
4
Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer.调节性T细胞与肿瘤相关树突状细胞之间的串扰削弱了胰腺癌的抗肿瘤免疫。
Cell Rep. 2017 Jul 18;20(3):558-571. doi: 10.1016/j.celrep.2017.06.062.
5
Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.19S蛋白酶体亚基的抑制标志着多种癌症中一种改变的细胞状态的出现。
Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):382-387. doi: 10.1073/pnas.1619067114. Epub 2016 Dec 27.
6
Targeting PD1-PDL1 immune checkpoint in plasmacytoid dendritic cell interactions with T cells, natural killer cells and multiple myeloma cells.靶向浆细胞样树突状细胞与T细胞、自然杀伤细胞和多发性骨髓瘤细胞相互作用中的PD1-PDL1免疫检查点。
Leukemia. 2015 Jun;29(6):1441-4. doi: 10.1038/leu.2015.11. Epub 2015 Jan 30.
7
A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib.一种新型 TLR-9 激动剂 C792 抑制浆细胞样树突状细胞诱导的骨髓瘤细胞生长并增强硼替佐米的细胞毒性。
Leukemia. 2014 Aug;28(8):1716-24. doi: 10.1038/leu.2014.46. Epub 2014 Jan 30.
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Leukemia. 2012 Apr;26(4):757-68. doi: 10.1038/leu.2011.256. Epub 2011 Sep 23.
10
Regulatory T cells and Foxp3.调节性 T 细胞和 Foxp3。
Immunol Rev. 2011 May;241(1):260-8. doi: 10.1111/j.1600-065X.2011.01018.x.