Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Department of Obstetrics and Gynecology №2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
BMC Womens Health. 2023 Aug 5;23(1):414. doi: 10.1186/s12905-023-02569-9.
The expression of vitamin D receptor in the normal endometrium and ovaries supports the role of vitamin D in local immunity and inflammatory cytokines regulation.
This study aimed to detect the relation between serum 25(OH)D and primary dysmenorrhea in Asian Adolescents.
Two hundred and five (205) adolescents complaining of primary dysmenorrhea (study group) were compared in this prospective study to matched controls (210 controls) after informed consent following the Helsinki Declaration. After thorough evaluation, including a thorough history and pelvic ultrasound examination, blood samples were collected from the studied adolescents to measure serum 25(OH)D and for vitamin D receptor TaqI (rs731236) genotyping. The studied adolescents' data were analyzed using the Pearson's correlation to detect the relation between serum 25(OH)D and primary dysmenorrhea (primary outcome). The secondary outcome measures the odds of primary dysmenorrhea in Asian adolescents with vitamin D receptor TaqI (rs731236) polymorphism.
The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls (16.17 ± 7.36 versus 17.65 ± 6.36 ng/ml, respectively), (P = 0.01). The correlation analysis showed a significant negative correlation between the serum 25(OH)D and visual analogue scale of dysmenorrhea (r = -0.9003, P < 0.0001). The studied-dysmenorrhea cases with vitamin D receptor T/t and t/t genotypes had significantly lower serum 25(OH)D (16.7 ± 8.05 and 14.4 ± 4.1 ng/ml, respectively) compared to controls (18.97 ± 6.7 and 21.4 ± 2.45 ng/ml, respectively), (P = 0.02 and 0.004, respectively). The VDR T/t and t/t polymorphisms significantly increase the odds of primary dysmenorrhea (OR 1367.2, P < 0.0001 and OR 106.2, P = 0.001, respectively).
The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls. The studied-dysmenorrhea cases with VDR T/t and t/t TaqI genotypes had significantly lower serum 25(OH)D compared to controls. The VDR T/t and t/t polymorphisms significantly increase the odds of primary dysmenorrhea.
维生素 D 受体在正常子宫内膜和卵巢中的表达支持维生素 D 在局部免疫和炎症细胞因子调节中的作用。
本研究旨在检测亚洲青少年血清 25(OH)D 与原发性痛经之间的关系。
在这项前瞻性研究中，205 名（205 名）主诉原发性痛经的青少年（研究组）与经知情同意后符合条件的对照组（210 名对照组）进行了比较。赫尔辛基宣言。在彻底评估后，包括详细的病史和盆腔超声检查，从研究中的青少年采集血液样本以测量血清 25(OH)D 和维生素 D 受体 TaqI(rs731236)基因分型。使用 Pearson 相关性分析研究青少年的数据，以检测血清 25(OH)D 与原发性痛经之间的关系（主要结局）。次要结局衡量亚洲青少年维生素 D 受体 TaqI(rs731236)多态性与原发性痛经的关系。
与对照组相比，研究痛经组的血清 25(OH)D 明显降低（分别为 16.17±7.36 和 17.65±6.36ng/ml，P=0.01）。相关性分析显示，血清 25(OH)D 与痛经视觉模拟评分呈显著负相关（r=-0.9003，P<0.0001）。维生素 D 受体 T/t 和 t/t 基因型的研究痛经病例的血清 25(OH)D 明显低于对照组（分别为 16.7±8.05 和 14.4±4.1ng/ml）（分别为 18.97±6.7 和 21.4±2.45ng/ml）（P=0.02 和 0.004）。VDR T/t 和 t/t 多态性显著增加原发性痛经的几率（OR 1367.2，P<0.0001 和 OR 106.2，P=0.001）。
与对照组相比，研究痛经组的血清 25(OH)D 明显降低。与对照组相比，维生素 D 受体 T/t 和 t/t TaqI 基因型的研究痛经病例的血清 25(OH)D 明显降低。VDR T/t 和 t/t 多态性显著增加原发性痛经的几率。
