Negash Abebe Worku, Tsehai Berhanu Andualem
Department of Biotechnology, College of Natural and Computational Science (CNCS), Adigrat University, P.O. Box 50, Adigrat, Ethiopia.
Department of Biotechnology, Institute of Biotechnology (IoB), University of Gondar, P.O. Box 196, Gondar, Ethiopia.
Int J Microbiol. 2020 Nov 3;2020:4374891. doi: 10.1155/2020/4374891. eCollection 2020.
Bacteriocins are multifunctional, ribosomally produced, proteinaceous substances with pronounced antimicrobial activity at certain concentrations. They are produced by bacteria and certain members of archaea to inhibit the growth of similar or closely related bacterial strains. These molecules have antimicrobial activity against pathogenic and deteriorating bacteria, which justifies their biotechnological potential. They are classified into 3 major classes based on their structural and physicochemical properties: class I bacteriocin, class II bacteriocin, and class III bacteriocin. Bacteriocins inhibit the growth of target organisms by functioning primarily on the cell envelope and by affecting gene expression and protein production within cells. The use of bacteriocins has been reported for the following: food preservation, diverse therapeutic purposes such as treatment of peptic ulcer, spermicidal agent, and woman care, anticancerous agent, veterinary use, skincare, and oral care, and also for plant growth promotion in agriculture among others.
细菌素是多功能的、核糖体合成的蛋白质物质，在特定浓度下具有显著的抗菌活性。它们由细菌和某些古菌产生，以抑制相似或密切相关细菌菌株的生长。这些分子对致病和腐败细菌具有抗菌活性，这证明了它们的生物技术潜力。根据其结构和物理化学性质，它们被分为三大类：I类细菌素、II类细菌素和III类细菌素。细菌素主要通过作用于细胞膜以及影响细胞内的基因表达和蛋白质产生来抑制靶标生物的生长。细菌素的用途包括：食品保鲜、多种治疗用途，如治疗消化性溃疡、杀精剂和女性护理、抗癌剂、兽医用途、皮肤护理和口腔护理，以及在农业中促进植物生长等。
