• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过脑室外引流使用低剂量组织纤溶酶原激活剂和脑蛋白水解物治疗重症脑室出血：一例报告

Using low-dose tissue plasminogen activator through external ventricular drain and Cerebrolysin for the treatment of severe intraventricular hemorrhage: A case report.

作者信息

Hoang Ngoc Nguyen, Van Tuyen Nguyen

机构信息

Stroke Center, 108 Military Central Hospital, Hanoi, Vietnam.

出版信息

SAGE Open Med Case Rep. 2020 Dec 25;8:2050313X20981464. doi: 10.1177/2050313X20981464. eCollection 2020.

DOI:10.1177/2050313X20981464
PMID:33489233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7768572/
Abstract

Acute obstructive hydrocephalus is a complication of intraventricular hemorrhage, which requires a combination of medical and surgical treatments. We report a clinical case of intraventricular hemorrhage extension secondary to a ruptured arteriovenous malformation, successfully treated with a combination of methods: endovascular embolization of arteriovenous malformation, external ventricular drainage, intraventricular fibrinolysis with low-dose recombinant tissue plasminogen activator, and medical treatment with the neurotrophic drug Cerebrolysin in combination with neurorehabilitation.

摘要

急性梗阻性脑积水是脑室内出血的一种并发症，需要药物和手术联合治疗。我们报告一例继发于动静脉畸形破裂的脑室内出血扩展的临床病例，通过以下联合方法成功治疗：动静脉畸形的血管内栓塞、脑室外引流、低剂量重组组织型纤溶酶原激活剂进行脑室内纤溶治疗，以及使用神经营养药物脑蛋白水解物联合神经康复进行药物治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/790f/7768572/f3492510fdb2/10.1177_2050313X20981464-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/790f/7768572/5f1b47466e6a/10.1177_2050313X20981464-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/790f/7768572/f91125fa27d4/10.1177_2050313X20981464-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/790f/7768572/e13893cf34e7/10.1177_2050313X20981464-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/790f/7768572/f3492510fdb2/10.1177_2050313X20981464-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/790f/7768572/5f1b47466e6a/10.1177_2050313X20981464-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/790f/7768572/f91125fa27d4/10.1177_2050313X20981464-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/790f/7768572/e13893cf34e7/10.1177_2050313X20981464-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/790f/7768572/f3492510fdb2/10.1177_2050313X20981464-fig4.jpg

相似文献

1
Using low-dose tissue plasminogen activator through external ventricular drain and Cerebrolysin for the treatment of severe intraventricular hemorrhage: A case report.通过脑室外引流使用低剂量组织纤溶酶原激活剂和脑蛋白水解物治疗重症脑室出血：一例报告
SAGE Open Med Case Rep. 2020 Dec 25;8:2050313X20981464. doi: 10.1177/2050313X20981464. eCollection 2020.
2
Recombinant tissue plasminogen activator in the treatment of intraventricular hemorrhage secondary to periventricular arteriovenous malformation before surgery: case report.重组组织型纤溶酶原激活剂在术前治疗脑室周围动静脉畸形继发脑室内出血中的应用：病例报告
Neurosurgery. 2003 Apr;52(4):964-8; discussion 968-9. doi: 10.1227/01.neu.0000053028.06474.c6.
3
Intraventricular thrombolysis after endovascular treatment of a ruptured arteriovenous malformation.破裂动静脉畸形血管内治疗后的脑室内溶栓治疗。
BMJ Case Rep. 2016 May 24;2016:bcr2016012408. doi: 10.1136/bcr-2016-012408.
4
Effectiveness of Combined External Ventricular Drainage with Intraventricular Fibrinolysis for the Treatment of Intraventricular Haemorrhage with Acute Obstructive Hydrocephalus.联合脑室外引流与脑室内纤溶治疗急性梗阻性脑积水性脑室内出血的疗效
Cerebrovasc Dis Extra. 2019;9(2):77-89. doi: 10.1159/000501530. Epub 2019 Aug 13.
5
Intraventricular thrombolysis after endovascular treatment of a ruptured arteriovenous malformation.破裂动静脉畸形血管内治疗后的脑室内溶栓
J Neurointerv Surg. 2017 Feb;9(2):e8. doi: 10.1136/neurintsurg-2016-012408.rep. Epub 2016 Jun 1.
6
Intraventricular tissue plasminogen activator for intraventricular hemorrhage caused by an arteriovenous malformation.脑室内组织型纤溶酶原激活剂治疗动静脉畸形所致脑室内出血。
J Clin Neurosci. 2014 Mar;21(3):526-9. doi: 10.1016/j.jocn.2013.04.031. Epub 2013 Oct 14.
7
Traumatic intraventricular hemorrhage treated with intraventricular recombinant-tissue plasminogen activator: technical case report.
Neurosurgery. 1998 Oct;43(4):966-9. doi: 10.1097/00006123-199810000-00150.
8
Intraventricular fibrinolysis versus external ventricular drainage alone in intraventricular hemorrhage: a meta-analysis.脑室内出血患者行脑室内纤维蛋白溶解与单纯脑室外引流的比较：一项荟萃分析。
Stroke. 2011 Oct;42(10):2776-81. doi: 10.1161/STROKEAHA.111.615724. Epub 2011 Aug 4.
9
Cohort study of intraventricular thrombolysis with recombinant tissue plasminogen activator for aneurysmal intraventricular hemorrhage.重组组织型纤溶酶原激活剂治疗动脉瘤性脑室内出血的队列研究
Neurosurgery. 2004 Sep;55(3):532-7; discussion 537-8. doi: 10.1227/01.neu.0000134473.98192.b1.
10
Intraventricular fibrinolysis and lumbar drainage for ventricular hemorrhage.脑室内纤溶治疗与腰椎引流治疗脑室出血
Stroke. 2009 Oct;40(10):3275-80. doi: 10.1161/STROKEAHA.109.551945. Epub 2009 Aug 13.

本文引用的文献

1
Efficacy and safety of cerebrolysin in neurorecovery after moderate-severe traumatic brain injury: results from the CAPTAIN II trial.脑活素治疗中重度颅脑损伤后神经功能恢复的疗效和安全性：CAPTAIN II 试验结果。
Neurol Sci. 2020 May;41(5):1171-1181. doi: 10.1007/s10072-019-04181-y. Epub 2020 Jan 2.
2
Randomized controlled trial of Cerebrolysin's effects on long-term histological outcomes and functional recovery in rats with moderate closed head injury.脑蛋白水解物对中度闭合性颅脑损伤大鼠长期组织学结果及功能恢复影响的随机对照试验
J Neurosurg. 2019 Sep 6;133(4):1072-1082. doi: 10.3171/2019.6.JNS191027. Print 2020 Oct 1.
3
Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.
溶栓清除脑室内出血治疗重症卒中：随机、多中心、多区域、安慰剂对照的CLEAR III试验结果
Lancet. 2017 Feb 11;389(10069):603-611. doi: 10.1016/S0140-6736(16)32410-2. Epub 2017 Jan 10.
4
Cerebrolysin and Recovery After Stroke (CARS): A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial.脑活素与卒中后恢复（CARS）：一项随机、安慰剂对照、双盲、多中心试验。
Stroke. 2016 Jan;47(1):151-9. doi: 10.1161/STROKEAHA.115.009416. Epub 2015 Nov 12.
5
Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.自发性脑出血管理指南：美国心脏协会/美国中风协会医疗保健专业人员指南。
Stroke. 2010 Sep;41(9):2108-29. doi: 10.1161/STR.0b013e3181ec611b. Epub 2010 Jul 22.
6
Medical complications after stroke.中风后的医学并发症。
Lancet Neurol. 2010 Jan;9(1):105-18. doi: 10.1016/S1474-4422(09)70266-2.
7
Intraventricular thrombolysis for massive intraventricular hemorrhage due to periventricular arteriovenous malformations: no absolute contraindications as rescue therapy prior to surgical repair or embolization?脑室周围动静脉畸形所致大量脑室内出血的脑室内溶栓治疗：作为手术修复或栓塞前的挽救治疗是否没有绝对禁忌证？
Clin Neurol Neurosurg. 2009 Jul;111(6):544-50. doi: 10.1016/j.clineuro.2009.02.006. Epub 2009 Mar 28.
8
Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage (CLEAR-IVH) clinical trial.评估脑室内出血加速溶解（CLEAR-IVH）临床试验的凝块溶解初步报告。
Acta Neurochir Suppl. 2008;105:217-20. doi: 10.1007/978-3-211-09469-3_41.
9
Outcome after spontaneous and arteriovenous malformation-related intracerebral haemorrhage: population-based studies.自发性及动静脉畸形相关脑出血后的结局：基于人群的研究
Brain. 2009 Feb;132(Pt 2):537-43. doi: 10.1093/brain/awn318. Epub 2008 Nov 28.
10
Cerebrolysin enhances functional recovery following focal cerebral infarction in rats.脑蛋白水解物可促进大鼠局灶性脑梗死术后的功能恢复。
Restor Neurol Neurosci. 2007;25(1):25-31.