Ekun Oloruntoba A, Daniel Folasade, Adebola Philip, Ajibare Adeola, Ekun Oyeronke O, Omogoroye Oluwafunso O, Ilori Oluwafemi S, Oluwasayo Bankole J, Oshundun Mary F, Oyegbami Sade R
Department of Medical Laboratory Science, College of Medicine, University of Lagos, Lagos, Nigeria.
Department of Medicine, Lagos State University, College of Medicine, Ikeja, Lagos, Nigeria.
Int J Hypertens. 2020 Dec 7;2020:6365947. doi: 10.1155/2020/6365947. eCollection 2020.
This study investigated plasma sodium/potassium ratio, markers of oxidative stress, renal function, and endothelial dysfunction in hypertensive Nigerians.
Five hundred forty-nine volunteers consisting of three hundred and twenty-four hypertensive and two hundred twenty-five controls participated in this study. Blood samples were collected from the participants and were analyzed for electrolytes, markers of oxidative stress, endothelial dysfunction, renal function, and inflammation, using ion-selective electrodes, spectrophotometric, and enzyme-linked immunosorbent assay methods, respectively.
The mean systolic blood pressure, mean diastolic blood pressure, mean arterial blood pressure, and body mass index (BMI) were significantly elevated among the hypertensive group when compared with control ( < 0.001). The mean sodium increased, while potassium and bicarbonate (HCO ) decreased ( < 0.001) in hypertensive volunteers. The sodium-potassium ratio (Na/K) and urea were raised ( < 0.001) in the hypertensive group when compared with the control. Glutathione, superoxide dismutase, nitric oxide (NO), and catalase were significantly reduced ( < 0.001) while malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), and ferritin were raised significantly ( < 0.001) in hypertensive participants. The odds of hypertension and its complications increased ( < 0.001) with an increase in BMI, Na/K, hs-CRP, MDA, and ferritin and a decrease in estimated glomerular filtration rate (eGFR), glutathione, superoxide dismutase, and catalase.
An increase in Na/K, urea, hs-CRP, ferritin, MDA, and BMI and a decrease in eGFR, glutathione, and superoxide dismutase were associated with an increased risk of hypertension complication. Abnormal values of markers of oxidative stress, inflammation, and endothelial function could impact deleterious effects on the cardiovascular system among hypertensive Nigerians. A decreased bicarbonate possibly suggests an occult acid-base imbalance among hypertensive volunteers.
本研究调查了尼日利亚高血压患者的血浆钠/钾比值、氧化应激标志物、肾功能和内皮功能障碍情况。
549名志愿者参与了本研究，其中包括324名高血压患者和225名对照者。采集参与者的血样，分别使用离子选择性电极法、分光光度法和酶联免疫吸附测定法分析电解质、氧化应激标志物、内皮功能障碍、肾功能和炎症指标。
与对照组相比，高血压组的平均收缩压、平均舒张压、平均动脉压和体重指数（BMI）显著升高（<0.001）。高血压志愿者的平均钠含量升高，而钾和碳酸氢盐（HCO）降低（<0.001）。与对照组相比，高血压组的钠钾比值（Na/K）和尿素升高（<0.001）。高血压参与者的谷胱甘肽、超氧化物歧化酶、一氧化氮（NO）和过氧化氢酶显著降低（<0.001），而丙二醛（MDA）、高敏C反应蛋白（hs-CRP）和铁蛋白显著升高（<0.001）。随着BMI、Na/K、hs-CRP、MDA和铁蛋白的增加以及估计肾小球滤过率（eGFR）、谷胱甘肽、超氧化物歧化酶和过氧化氢酶的降低，高血压及其并发症的几率增加（<0.001）。
Na/K、尿素、hs-CRP、铁蛋白、MDA和BMI的升高以及eGFR、谷胱甘肽和超氧化物歧化酶的降低与高血压并发症风险增加有关。氧化应激、炎症和内皮功能标志物的异常值可能对尼日利亚高血压患者的心血管系统产生有害影响。碳酸氢盐降低可能提示高血压志愿者存在隐匿性酸碱失衡。
