沙特阿拉伯一家三级护理医院术后伤口感染中耐药性细菌病原体的分离与检测
Isolation and Detection of Drug-Resistant Bacterial Pathogens in Postoperative Wound Infections at a Tertiary Care Hospital in Saudi Arabia.
作者信息
Al-Said Hamdi M, Alghamdi Ahmed, Ashgar Sami S, Jalal Naif A, Faidah Hani S, Johargy Ayman K, Momenah Aiman M, Barhameen Abeer A, Hariri Sumyya H, Bantun Farkad, Althobiany Essa, Khidir Elshiekh B
机构信息
Department of Microbiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Department of Medical Microbiology, Al-Noor Specialist Hospital, Makkah, Saudi Arabia.
出版信息
Saudi J Med Med Sci. 2023 Jul-Sep;11(3):229-234. doi: 10.4103/sjmms.sjmms_405_22. Epub 2023 Jul 15.
BACKGROUND
Surgical site infections (SSIs), especially when caused by multidrug-resistant (MDR) bacteria, are a major healthcare concern worldwide. For optimal treatment and prevention of antimicrobial resistance, it is important for clinicians to be aware of local drug-resistant bacterial pathogens that cause SSIs.
OBJECTIVE
To determine the frequency patterns of drug-resistant bacterial strains causing SSIs at a tertiary care hospital in Saudi Arabia.
METHODS
This retrospective study was conducted at the Microbiology laboratory of Al-Noor Specialist Hospital, Makkah, Saudi Arabia, and included wound swab samples from all cases of SSI between January 01, 2017, and December 31, 2021. The swabs were processed for the identification of bacterial strains and their resistance pattern to antibiotics according to the Clinical and Laboratory Standards Institute.
RESULTS
A total of 5409 wound swabs were analyzed, of which 3604 samples (66.6%) were from male. Most samples were from the Department of Surgery (43.3%). A total of 14 bacterial strains were isolated, of which 9 were Gram-negative bacteria. The most common isolates were , followed by , , , methicillin-resistant (MRSA), vancomycin-resistant Enterococci (VRE), and vancomycin-resistant (VRSA). In terms of MDR in 2021, the highest rate of carbapenem-resistance was in (97%). MDR was as follows: , 97%; , 81%; , 71%; MRSA, 60%; , 33%; VRE, 22%; and VRSA, 2%.
CONCLUSION
This study showed that in the city of Makkah, Saudi Arabia, the rates of MDR bacteria are high, with the majority being Gram-negative.
背景
手术部位感染（SSIs），尤其是由多重耐药（MDR）细菌引起的感染，是全球医疗保健领域的一个主要问题。为了实现对抗菌药物耐药性的最佳治疗和预防，临床医生了解引起SSIs的当地耐药细菌病原体非常重要。
目的
确定沙特阿拉伯一家三级护理医院中引起SSIs的耐药菌株的频率模式。
方法
这项回顾性研究在沙特阿拉伯麦加的努尔专科医院微生物实验室进行，纳入了2017年1月1日至2021年12月31日期间所有SSI病例的伤口拭子样本。根据临床和实验室标准协会的方法，对拭子进行处理，以鉴定细菌菌株及其对抗生素的耐药模式。
结果
共分析了5409份伤口拭子，其中3604份样本（66.6%）来自男性。大多数样本来自外科（43.3%）。共分离出14种细菌菌株，其中9种为革兰氏阴性菌。最常见的分离株是 ，其次是 、 、 、耐甲氧西林金黄色葡萄球菌（MRSA）、耐万古霉素肠球菌（VRE）和耐万古霉素金黄色葡萄球菌（VRSA）。在2021年的多重耐药方面，碳青霉烯耐药率最高的是 （97%）。多重耐药情况如下： ，97%； ，81%； ，71%；MRSA，60%； ，33%；VRE，22%；VRSA，2%。
结论
本研究表明，在沙特阿拉伯麦加市，多重耐药细菌的发生率很高，大多数为革兰氏阴性菌。
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