Valasques Junior Gildomar Lima, Dos Santos Jener David Gonçalves, Chaves Pedro Felipe Pereira, Cordeiro Lucimara Mach Côrtes, de Jesus Cleisiane Lima, de Lima Flávia Oliveira, Boffo Elisangela Fabiana, de Assis Sandra Aparecida
Enzymology and Fermentation Technology Laboratory, Health Department, State University of Feira de Santana, Av Transnordestina, km 0, BR 116, Feira de Santana, BA CEP 44036-900 Brazil.
University Veterinary Hospital, Federal University of Agreste of Pernambuco, Garanhuns, PE Brazil.
3 Biotech. 2021 Feb;11(2):73. doi: 10.1007/s13205-020-02635-1. Epub 2021 Jan 13.
sp. are yeasts that are commercially important due to their production of glycolipid biosurfactants, squalene, itaconic acid, and exopolysaccharide. The search for other analgesia inducing drugs, such as opiates and non-steroidal anti-inflammatory drugs (NSAIDs), as alternatives is beneficial. In this study, the antinociceptive and anti-inflammatory actions of α-d-mannan were studied using acetic acid-induced writhing, open field test, formalin test, and carrageenan-induced paw oedema tests in mice. The α-d-mannan obtained from sp. was confirmed by methylation analysis, 1D and 2D NMR spectroscopic analysis, and GC-MS. The results show that α-d-mannan from sp. has analgesic and anti-inflammatory activities.
The online version contains supplementary material available at 10.1007/s13205-020-02635-1.
某些酵母属物种由于能够产生糖脂生物表面活性剂、角鲨烯、衣康酸和胞外多糖而具有重要的商业价值。寻找其他诱导镇痛的药物，如阿片类药物和非甾体抗炎药（NSAIDs）作为替代品是有益的。在本研究中，使用乙酸诱导的扭体试验、旷场试验、福尔马林试验和角叉菜胶诱导的小鼠爪肿胀试验研究了α-d-甘露聚糖的抗伤害感受和抗炎作用。从某些酵母属物种中获得的α-d-甘露聚糖通过甲基化分析、一维和二维核磁共振光谱分析以及气相色谱-质谱联用进行了确认。结果表明，来自某些酵母属物种的α-d-甘露聚糖具有镇痛和抗炎活性。
在线版本包含可在10.1007/s13205-020-02635-1获取的补充材料
