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合并症可能是新型冠状病毒肺炎发病的一个风险因素:基于网络调查的证据。

Comorbidities might be a risk factor for the incidence of COVID-19: Evidence from a web-based survey.

作者信息

Alam Mohammad Rahanur, Kabir Md Ruhul, Reza Sompa

机构信息

Department of Food Technology and Nutrition Science, Noakhali Science and Technology University, Bangladesh.

Institute of Nutrition and Food Science, University of Dhaka, Bangladesh.

出版信息

Prev Med Rep. 2021 Jan 7;21:101319. doi: 10.1016/j.pmedr.2021.101319. eCollection 2021 Mar.

Abstract

The global pandemic of COVID-19 is posing the biggest threat to humanity through its ubiquitous effect of unfathomable magnitude. Although COVID-19 is a viral disease, there might be an association between different comorbidities and the occurrence of the disease. Our study aims to determine the association between the COVID-19 infection and pre-existing comorbidities such as asthma, diabetes, liver disease, lung disease, heart disease, kidney disease, hypertension, and obesity through a web-based self-reported survey. Univariate and multivariate logistic regression analyses were done using these risk factors as independent variables. A total of 780,961 participants from 183 different countries and territories participated in this study. Among them, 1516 participants were diagnosed with COVID-19 prior to this study. A significant risk association was observed for age above 60 years, female gender, as well as different pre-existing disease conditions such as diabetes, kidney disease, liver disease, and heart diseases. Asthma and diabetes were the major dominant comorbidities among patients, and patients with existing diabetes were more likely to develop the disease than others who did not diagnose as diseased. Therefore, older adults, females, as well as people with comorbidities such as diabetes mellitus, heart disease, kidney disease, and liver disease are the most vulnerable population for COVID-19. However, further studies should be carried out to explain the pathway of these risk associations.

摘要

新型冠状病毒肺炎(COVID-19)全球大流行正通过其难以估量的广泛影响对人类构成最大威胁。尽管COVID-19是一种病毒性疾病,但不同的合并症与该疾病的发生之间可能存在关联。我们的研究旨在通过一项基于网络的自我报告调查,确定COVID-19感染与哮喘、糖尿病、肝病、肺病、心脏病、肾病、高血压和肥胖等既往合并症之间的关联。以这些风险因素作为自变量进行单因素和多因素逻辑回归分析。来自183个不同国家和地区的780961名参与者参与了本研究。其中,1516名参与者在本研究之前被诊断为COVID-19。观察到60岁以上年龄、女性性别以及糖尿病、肾病、肝病和心脏病等不同的既往疾病状况存在显著的风险关联。哮喘和糖尿病是患者中的主要合并症,患有糖尿病的患者比未被诊断为患病的其他人更易感染该疾病。因此,老年人、女性以及患有糖尿病、心脏病、肾病和肝病等合并症的人是COVID-19最脆弱的人群。然而,应开展进一步研究以解释这些风险关联的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90f6/7811036/cea0d4251aed/gr1.jpg

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