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Dermatol Online J. 2018 Feb 15;24(2):13030/qt4rc0q7vx.
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A systematic review of fluconazole resistance in clinical isolates of Cryptococcus species.一项关于隐球菌属临床分离株中氟康唑耐药性的系统评价。
Mycoses. 2018 May;61(5):290-297. doi: 10.1111/myc.12747. Epub 2018 Feb 14.
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Innate immune evasion strategies against Cryptococcal meningitis caused by .针对由……引起的新型隐球菌性脑膜炎的天然免疫逃避策略
Exp Ther Med. 2017 Dec;14(6):5243-5250. doi: 10.3892/etm.2017.5220. Epub 2017 Sep 29.
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Primary Cutaneous Cryptococcosis: A New Case of This Rare Entity.原发性皮肤隐球菌病：这一罕见疾病的一例新病例。
Open Forum Infect Dis. 2017 Jan 19;4(1):ofw276. doi: 10.1093/ofid/ofw276. eCollection 2017 Winter.
6
Disseminated cryptococcosis manifested as a single tumor in an immunocompetent patient, similar to the cutaneous primary forms.播散性隐球菌病在免疫功能正常的患者中表现为单个肿瘤，类似于皮肤原发性形式。
An Bras Dermatol. 2016 Sep-Oct;91(5 suppl 1):29-31. doi: 10.1590/abd1806-4841.20164582.
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Cutaneous Cryptococcus: marker for disseminated infection.皮肤隐球菌病：播散性感染的标志物
BMJ Case Rep. 2015 Jul 21;2015:bcr2015210898. doi: 10.1136/bcr-2015-210898.
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Systemic Review of Published Reports on Primary Cutaneous Cryptococcosis in Immunocompetent Patients.免疫功能正常患者原发性皮肤隐球菌病的已发表报告的系统评价。
Mycopathologia. 2015 Aug;180(1-2):19-25. doi: 10.1007/s11046-015-9880-7. Epub 2015 Mar 4.
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Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.新型隐球菌和格特隐球菌是隐球菌病的病原体。
Cold Spring Harb Perspect Med. 2014 Jul 1;4(7):a019760. doi: 10.1101/cshperspect.a019760.
10
The tools for virulence of Cryptococcus neoformans.新型隐球菌毒力相关工具。
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原发性皮肤隐球菌病成功治疗后发生的暴发性隐球菌性脑膜脑炎。

Fulminant cryptococcal meningoencephalitis after successful treatment of primary cutaneous cryptococcosis.

作者信息

Romiopoulos Iordanis, Pana Zoi Dorothea, Pyrpasopoulou Athina, Linardou Ioanna, Avdelidi Eugenia, Sidiropoulou Maria, Chatzidrosou Eleni, Ioannides Dimitrios, Karagiannis Asterios, Roilides Emmanuel

机构信息

MD, Infectious Diseases Unit, Hippokration Hospital, 54642 Thessaloniki, Greece.

MD, PhD, Infectious Diseases Unit, Hippokration Hospital, 54642 Thessaloniki, Greece.

出版信息

Germs. 2020 Dec 28;10(4):388-391. doi: 10.18683/germs.2020.1232. eCollection 2020 Dec.

DOI:10.18683/germs.2020.1232
PMID:33489955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7811852/
Abstract

INTRODUCTION

Cryptococcal meningoencephalitis is a life-threatening disease affecting mainly immunocompromised hosts.

CASE REPORT

We present a case of a 64-year-old immunocompetent patient, who initially developed a traumatic scalp skin infection due to . The patient received oral fluconazole and subsequently liposomal amphotericin B due to the development of resistance with resolution of the infection. Two years later, during chemotherapy for newly diagnosed gastric and lung cancer, he developed fulminant cryptococcal meningoencephalitis, which did not respond to liposomal amphotericin B and flucytosine.

CONCLUSIONS

To our knowledge, this is the first case of fulminant cryptococcal meningoencephalitis following long latency after adequately treated primary cutaneous infection.

摘要

引言

隐球菌性脑膜脑炎是一种主要影响免疫功能低下宿主的危及生命的疾病。

病例报告

我们报告一例64岁免疫功能正常的患者，该患者最初因……发生创伤性头皮皮肤感染。患者接受口服氟康唑治疗，随后因出现耐药且感染得到缓解而接受脂质体两性霉素B治疗。两年后，在新诊断的胃癌和肺癌化疗期间，他发生了暴发性隐球菌性脑膜脑炎，对脂质体两性霉素B和氟胞嘧啶均无反应。

结论

据我们所知，这是首例在原发性皮肤感染得到充分治疗后经过长时间潜伏期发生暴发性隐球菌性脑膜脑炎的病例。