Calabrò Marco, Rinaldi Carmela, Santoro Giuseppe, Crisafulli Concetta
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy.
AIMS Neurosci. 2020 Dec 16;8(1):86-132. doi: 10.3934/Neuroscience.2021005. eCollection 2021.
Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older people, which severely impairs patients' quality of life. In the recent years, the number of affected individuals has seen a rapid increase. It is estimated that up to 107 million subjects will be affected by 2050 worldwide. Research in this area has revealed a lot about the biological and environmental underpinnings of Alzheimer, especially its correlation with β-Amyloid and Tau related mechanics; however, the precise molecular events and biological pathways behind the disease are yet to be discovered. In this review, we focus our attention on the biological mechanics that may lie behind Alzheimer development. In particular, we briefly describe the genetic elements and discuss about specific biological processes potentially associated with the disease.
阿尔茨海默病是一种进行性神经退行性疾病，主要影响老年人，严重损害患者的生活质量。近年来，受影响个体的数量迅速增加。据估计，到2050年全球将有多达1.07亿人受到影响。该领域的研究已经揭示了许多关于阿尔茨海默病的生物学和环境基础，特别是其与β-淀粉样蛋白和 Tau 相关机制的关联；然而，该疾病背后的确切分子事件和生物学途径仍有待发现。在这篇综述中，我们将注意力集中在阿尔茨海默病发展背后可能存在的生物学机制上。特别是，我们简要描述了遗传因素，并讨论了可能与该疾病相关的特定生物学过程。
