Synaptic Pruning in Alzheimer's Disease: Role of the Complement System.
作者信息
Brucato Frederic H, Benjamin Daniel E
机构信息
Cascade Biotechnology Inc., Princeton Corporate Plaza 1 Deer Park Dr., Suite D5. Monmouth Junction NJ 08852.
出版信息
Glob J Med Res. 2020;20(6). doi: 10.34257/gjmrfvol20is6pg1. Epub 2020 Jun 29.
Abstract
摘要
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Am J Lifestyle Med. 2019 May 9;13(5):451-461. doi: 10.1177/1559827619843465. eCollection 2019 Sep-Oct.
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Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.补体 C3 在人类 AD 脑中被激活，并在淀粉样变性和 Tau 病的小鼠模型中导致神经退行性变。
Cell Rep. 2019 Aug 20;28(8):2111-2123.e6. doi: 10.1016/j.celrep.2019.07.060.
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Somatic mutation that affects transcription factor binding upstream of CD55 in the temporal cortex of a late-onset Alzheimer disease patient.一位晚发性阿尔茨海默病患者颞叶皮质中影响 CD55 上游转录因子结合的体细胞突变。
Hum Mol Genet. 2019 Aug 15;28(16):2675-2685. doi: 10.1093/hmg/ddz085.
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5
Inflammatory biomarkers in Alzheimer's disease plasma.阿尔茨海默病患者血浆中的炎症生物标志物。
Alzheimers Dement. 2019 Jun;15(6):776-787. doi: 10.1016/j.jalz.2019.03.007. Epub 2019 Apr 30.
6
is a novel risk gene for Alzheimer's disease in Han Chinese.是汉族人群中阿尔茨海默病的一个新的风险基因。
Natl Sci Rev. 2019 Mar;6(2):257-274. doi: 10.1093/nsr/nwy127. Epub 2018 Nov 5.
7
Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3β signaling pathways.补体 C3a 受体拮抗剂通过糖原合酶激酶 3β信号通路减弱 tau 过度磷酸化。
Eur J Pharmacol. 2019 May 5;850:135-140. doi: 10.1016/j.ejphar.2019.02.020. Epub 2019 Feb 14.
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Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.小胶质细胞导致精神分裂症患者来源的突触修剪模型中突触消除增加。
Nat Neurosci. 2019 Mar;22(3):374-385. doi: 10.1038/s41593-018-0334-7. Epub 2019 Feb 4.
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Complement protein C5a enhances the β-amyloid-induced neuro-inflammatory response in microglia in Alzheimer's disease.补体蛋白C5a增强了阿尔茨海默病中β-淀粉样蛋白诱导的小胶质细胞神经炎症反应。
Med Sci (Paris). 2018 Oct;34 Focus issue F1:116-120. doi: 10.1051/medsci/201834f120. Epub 2018 Nov 7.
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Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.tau 病中的突触蛋白组变化及 C1q 抗体对 tau 诱导的突触丢失的挽救作用。
Neuron. 2018 Dec 19;100(6):1322-1336.e7. doi: 10.1016/j.neuron.2018.10.014. Epub 2018 Nov 1.
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