Colombo Antonio, Martinelli Boneschi Filippo, Beretta Sandro, Bresolin Nereo, Versino Maurizio, Lorusso Lorenzo, Spagnoli Diego, Nastasi Giulia, Vallauri Davide, Rota Stefania, Repaci Maria, Ferrarini Massimo, Pozzato Mattia, Princiotta Cariddi Lucia, Tabaee Damavandi Payam, Carimati Federico, Banfi Paola, Clemenzi Alessandro, Marelli Margherita, Giorgianni Andrea, Vinacci Gabriele, Mauri Marco, Melzi Paola, Di Stefano Maria, Tetto Antonio, Canesi Margherita, Salmaggi Andrea
SNO (Society of Hospital Neurosciences, Italy) and Polo Neurologico Brianteo, Seregno, MB, Italy.
Dino Ferrari Centre, Department of Pathophysiology and Transplantation (DEPT), University of Milan and IRCCS Ca' Granda Foundation Ospedale Maggiore Policlinico, Neurology Unit and MS Center Milan, Italy.
eNeurologicalSci. 2020 Dec 22;22:100306. doi: 10.1016/j.ensci.2020.100306. eCollection 2021 Mar.
Posterior reversible encephalopathy cases are increasingly being reported in patients affected by COVID-19, but the largest series so far only includes 4 patients. We present a series of 6 patients diagnosed with PRES during COVID-19 hospitalized in 5 Centers in Lombardia, Italy. 5 out of the 6 patients required intensive care assistence and seizures developed at weaning from assisted ventilation. 3 out of 6 patients underwent cerebrospinal fluid analysis which was normal in all cases, with negative PCR for Sars-CoV-2 genome search. PRES occurrence may be less rare than supposed in COVID-19 patients and a high suspicion index is warranted for prompt diagnosis and treatment.
越来越多的报告称，新冠肺炎患者出现了后部可逆性脑病病例，但迄今为止最大的病例系列仅包括4例患者。我们报告了在意大利伦巴第大区5个中心住院的6例新冠肺炎确诊期间被诊断为PRES的患者。6例患者中有5例需要重症监护，在撤机时出现癫痫发作。6例患者中有3例接受了脑脊液分析，所有病例结果均正常，Sars-CoV-2基因组检测PCR结果为阴性。PRES在新冠肺炎患者中的发生率可能比想象的要高，因此需要高度怀疑指数以进行及时诊断和治疗。
