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用于骨生成的钛基材料的多孔结构与表面改性:综述

Porous construction and surface modification of titanium-based materials for osteogenesis: A review.

作者信息

Wang Rui, Ni Shilei, Ma Li, Li Meihua

机构信息

Department of Stomatology, The Second Hospital of Jilin University, Changchun, China.

Department of Plastic and Aesthetic Surgery, Hospital of Stomatology, Jilin University, Changchun, China.

出版信息

Front Bioeng Biotechnol. 2022 Aug 25;10:973297. doi: 10.3389/fbioe.2022.973297. eCollection 2022.

Abstract

Titanium and titanium alloy implants are essential for bone tissue regeneration engineering. The current trend is toward the manufacture of implants from materials that mimic the structure, composition and elasticity of bones. Titanium and titanium alloy implants, the most common materials for implants, can be used as a bone conduction material but cannot promote osteogenesis. In clinical practice, there is a high demand for implant surfaces that stimulate bone formation and accelerate bone binding, thus shortening the implantation-to-loading time and enhancing implantation success. To avoid stress shielding, the elastic modulus of porous titanium and titanium alloy implants must match that of bone. Micro-arc oxidation technology has been utilized to increase the surface activity and build a somewhat hard coating on porous titanium and titanium alloy implants. More recently, a growing number of researchers have combined micro-arc oxidation with hydrothermal, ultrasonic, and laser treatments, coatings that inhibit bacterial growth, and acid etching with sand blasting methods to improve bonding to bone. This paper summarizes the reaction at the interface between bone and implant material, the porous design principle of scaffold material, MAO technology and the combination of MAO with other technologies in the field of porous titanium and titanium alloys to encourage their application in the development of medical implants.

摘要

钛及钛合金植入物对于骨组织再生工程至关重要。当前的趋势是使用模仿骨骼结构、成分和弹性的材料来制造植入物。钛及钛合金植入物是最常用的植入材料,可用作骨传导材料,但不能促进成骨。在临床实践中,对能够刺激骨形成并加速骨结合的植入物表面有很高的需求,从而缩短植入到加载的时间并提高植入成功率。为避免应力遮挡,多孔钛及钛合金植入物的弹性模量必须与骨相匹配。微弧氧化技术已被用于提高多孔钛及钛合金植入物的表面活性并形成一定硬度的涂层。最近,越来越多的研究人员将微弧氧化与水热、超声和激光处理、抑制细菌生长的涂层以及喷砂酸蚀方法相结合,以改善与骨的结合。本文总结了骨与植入材料界面处的反应、支架材料的多孔设计原理、微弧氧化技术以及微弧氧化与多孔钛及钛合金领域其他技术的结合,以促进它们在医用植入物开发中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298e/9452912/f66c5d88c165/fbioe-10-973297-g001.jpg

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