Nossal R
Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland 20892.
Biophys J. 1988 Mar;53(3):349-59. doi: 10.1016/S0006-3495(88)83112-6.
Models relating to the gelation and elasticity of complex cytoskeletal networks are formulated and investigated. Kinetic equations for reversible elongation of nucleated actin filaments are analyzed when the filaments are acted upon by capping proteins and cross-linking factors. Analytical expressions are obtained that relate the low frequency elastic shear modulus of a network, G, to chain growth kinetics, the number of nucleation sites, monomer concentration, and the amount of capping and cross-linking protein. Elasticity curves that relate G to such factors as the association constant for cross-linking are derived and then used to determine solation-gelation phase contours.
构建并研究了与复杂细胞骨架网络的凝胶化和弹性相关的模型。当有封端蛋白和交联因子作用于丝状肌动蛋白丝时，分析了其可逆伸长的动力学方程。得到了将网络的低频弹性剪切模量G与链生长动力学、成核位点数量、单体浓度以及封端和交联蛋白量相关联的解析表达式。推导了将G与交联缔合常数等因素相关联的弹性曲线，然后用于确定溶胶-凝胶相轮廓。
