Rom-Bugoslavskaia E S, Komarova I V, Bondarenko L A
Biull Eksp Biol Med. 1988 Feb;105(2):221-4.
Seasonal peculiarities of adrenal mineralocorticoid function and some aspects of its regulation have been studied in experiments on male Wistar rats. It has been found that changes in aldosteronemia and aldosteronurea were maximum in spring and minimum in summer--autumn period. The highest indices of aldosterone metabolic clearance from plasma were observed in winter with the following progressing decrease and a small increase in autumn. The diagram of melatonin content in the epiphysis of experimental rats was the same. Hypokinesia attenuated aldosteronurea during all the investigation periods, preserving the character of aldosterone secretion year curve. PRA level changed irrespective of aldosterone levels in plasma and urea. It has been concluded that a certain stability of mineralocorticoid adrenal function seasonal rhythms has different regulating effects.
在对雄性Wistar大鼠进行的实验中，研究了肾上腺盐皮质激素功能的季节性特点及其调节的某些方面。发现醛固酮血症和醛固酮尿的变化在春季最大，在夏秋季最小。血浆中醛固酮代谢清除率的最高指标在冬季观察到，随后逐渐下降，秋季略有上升。实验大鼠松果体中褪黑素含量的变化曲线与之相同。在所有研究期间，运动减少减弱了醛固酮尿，保留了醛固酮分泌年曲线的特征。血浆肾素活性（PRA）水平的变化与血浆和尿液中醛固酮水平无关。得出的结论是，肾上腺盐皮质激素功能季节性节律的某种稳定性具有不同的调节作用。
