Mothersill C, Cusack A, Seymour C B
Saint Luke's Hospital, Rathgar, Dublin.
Br J Radiol. 1988 Mar;61(723):226-30. doi: 10.1259/0007-1285-61-723-226.
An explant outgrowth technique to determine the radiation response of five different human organs (bladder, oesophagus, colon, breast and thyroid) is described. In each case except thyroid, where malignancies are rare, data are presented for normal and malignant tissue. Results show that variations in response, consistent with those observed in vivo, can be measured. Tumours were in all cases highly resistant to radiation relative to their corresponding normal tissue. Possible reasons for this are discussed. The method may prove useful in the prediction of the radiobiological response for tumour and surrounding normal tissue where post-operative therapy is planned.
本文描述了一种用于确定五种不同人体器官（膀胱、食道、结肠、乳腺和甲状腺）辐射反应的外植体生长技术。除甲状腺外（甲状腺恶性肿瘤罕见），每种情况均给出了正常组织和恶性组织的数据。结果表明，可以测量与体内观察到的反应一致的反应变化。在所有情况下，肿瘤相对于其相应的正常组织对辐射具有高度抗性。文中讨论了造成这种情况的可能原因。该方法可能在计划术后治疗的肿瘤及周围正常组织的放射生物学反应预测中证明有用。
