Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.
Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.
J Mol Cell Biol. 2021 May 7;13(2):79-90. doi: 10.1093/jmcb/mjaa080.
Vascular remodeling is a pathological basis of various disorders. Therefore, it is necessary to understand the occurrence, prevention, and treatment of vascular remodeling. Krüppel-like factor 5 (KLF5) has been identified as a significant factor in cardiovascular diseases during the last two decades. This review provides a mechanism network of function and regulation of KLF5 in vascular remodeling based on newly published data and gives a summary of its potential therapeutic applications. KLF5 modulates numerous biological processes, which play essential parts in the development of vascular remodeling, such as cell proliferation, phenotype switch, extracellular matrix deposition, inflammation, and angiogenesis by altering downstream genes and signaling pathways. Considering its essential functions, KLF5 could be developed as a potent therapeutic target in vascular disorders.
血管重构是多种疾病的病理基础。因此，有必要了解血管重构的发生、预防和治疗。在过去的二十年中，Krüppel 样因子 5（KLF5）已被确定为心血管疾病的重要因素。本综述根据新发表的数据提供了 KLF5 在血管重构中的功能和调节机制网络，并总结了其潜在的治疗应用。KLF5 通过改变下游基因和信号通路，调节细胞增殖、表型转换、细胞外基质沉积、炎症和血管生成等许多生物学过程，在血管重构的发展中发挥重要作用。鉴于其重要功能，KLF5 可能成为血管疾病的潜在有效治疗靶点。
