Microbiota, Epigenetics, and Trained Immunity. Convergent Drivers and Mediators of the Asthma Trajectory from Pregnancy to Childhood.
作者信息
Lynch Susan V, Vercelli Donata
机构信息
Division of Gastroenterology, Department of Medicine, University of California, San Francisco, California; and.
Department of Cellular and Molecular Medicine & Asthma and Airway Disease Research Center, University of Arizona, Tucson, Arizona.
出版信息
Am J Respir Crit Care Med. 2021 Apr 1;203(7):802-808. doi: 10.1164/rccm.202010-3779PP.
Abstract
摘要
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Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention.哮喘的一级预防：从风险和保护因素到有针对性的预防策略。
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Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition.未成熟人胎儿 B 细胞中的自身反应性与共生菌识别有关。
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Targeting maternal immune function during pregnancy for asthma prevention in offspring: Harnessing the "farm effect"?针对孕期母体免疫功能以预防子代哮喘：利用“农场效应”？
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Defining trained immunity and its role in health and disease.定义训练免疫及其在健康和疾病中的作用。
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Training the Fetal Immune System Through Maternal Inflammation-A Layered Hygiene Hypothesis.通过母体炎症训练胎儿免疫系统——分层卫生假说。
Front Immunol. 2020 Feb 11;11:123. doi: 10.3389/fimmu.2020.00123. eCollection 2020.
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Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice.孕期母体肠道微生物群影响小鼠后代代谢表型。
Science. 2020 Feb 28;367(6481). doi: 10.1126/science.aaw8429.
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Nat Med. 2020 Apr;26(4):599-607. doi: 10.1038/s41591-020-0761-3. Epub 2020 Feb 24.
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T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children.T 细胞表型与阿米什和哈特派儿童的血清 IgE 水平有关。
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Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.肠道微生物代谢产物丁酸盐通过表观遗传和 GPR109a 介导的机制预防蛋白尿性肾病。
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