Healthy Aging Phenotypes Research Unit - "Salus in Apulia Study" - National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Bari, Italy.
Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
J Am Med Dir Assoc. 2021 Mar;22(3):598-605. doi: 10.1016/j.jamda.2020.12.026. Epub 2021 Jan 23.
We first estimated the prevalence of physical frailty in older subjects from the population-based Salus in Apulia Study (Apulia, Southern Italy), and its impact on all-cause mortality. Second, we explored the relationship between multimorbidity and physical frailty.
Cross-sectional and longitudinal analyses from a population-based study.
We analyzed data from the Salus in Apulia study, a population-based sample of 1929 subjects aged 65 years and older.
These older participants underwent clinical, physical, and laboratory assessments. Physical frailty was operationalized using slightly modified Fried criteria. Multimorbidity status was defined as the co-presence of 2 or more chronic conditions.
The overall prevalence of physical frailty in this older population from Southern Italy was 14.8% [95% confidence interval (CI): 13.26-16.49]. Physical frailty subjects were significantly older (P < .01), had a lower educational level (P < .01), increased executive dysfunction (P < .01), higher serum levels interleukin-6 (P < .01), and white blood cells (P = .01). Multimorbidity status (P < .01), diabetes mellitus (P = .05), peripheral age-related hearing loss (P < .01), cognitive impairment (P < .01), chronic obstructive pulmonary disease (P = .02), and metabolic syndrome (P = .02) were also directly related to physical frailty. Apathy increased according to the severity of physical frailty status (P = .02). There was a significant increased risk of all-cause mortality for physical frailty subjects (hazard ratio: 1.48; 95% CI: 1.03-2.12, adjusted for age and sex) during the observation from the date of enrollment to the date of death (mean ± SD: 55.70 ± 22.19 months, median: 54 months).
Frailty is the consequence of the contributory action of the aging process and some chronic diseases that hasten some of the changes concurrent with aging.
我们首先估计了来自基于人群的普利亚萨卢斯研究（意大利南部普利亚）的老年受试者中身体虚弱的流行率及其对全因死亡率的影响。其次，我们探讨了多病共存与身体虚弱之间的关系。
基于人群的研究的横断面和纵向分析。
我们分析了来自普利亚萨卢斯研究的数据，该研究是一项基于人群的样本，包括 1929 名年龄在 65 岁及以上的受试者。
这些老年参与者接受了临床、身体和实验室评估。身体虚弱是使用稍微修改的弗莱德标准来操作的。多病共存状态定义为同时存在 2 种或多种慢性疾病。
意大利南部这个老年人群的总体身体虚弱患病率为 14.8%[95%置信区间（CI）：13.26-16.49]。身体虚弱的受试者年龄明显更大（P<.01），教育程度更低（P<.01），执行功能障碍更严重（P<.01），血清白细胞介素-6（P<.01）和白细胞水平更高（P=.01）。多病共存状态（P<.01）、糖尿病（P=.05）、与年龄相关的外周听力损失（P<.01）、认知障碍（P<.01）、慢性阻塞性肺疾病（P=.02）和代谢综合征（P=.02）也与身体虚弱直接相关。随着身体虚弱状况的严重程度增加，冷漠程度也会增加（P=.02）。在从登记日期到死亡日期的观察期间，身体虚弱受试者的全因死亡率有显著增加（危险比：1.48；95%CI：1.03-2.12，调整年龄和性别）（平均±标准差：55.70±22.19 个月，中位数：54 个月）。
虚弱是衰老过程和一些加速与衰老相关的某些变化的慢性疾病共同作用的结果。
