动态铁的表观遗传调控。
Epigenomic regulation by labile iron.
机构信息
John P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
出版信息
Free Radic Biol Med. 2021 Jul;170:44-49. doi: 10.1016/j.freeradbiomed.2021.01.026. Epub 2021 Jan 22.
Iron is an essential micronutrient metal for cellular functions but can generate highly reactive oxygen species resulting in oxidative damage. For these reasons its uptake and metabolism is highly regulated. A small but dynamic fraction of ferrous iron inside the cell, termed intracellular labile iron, is redox-reactive and ready to participate multiples reactions of intracellular enzymes. Due to its nature its determination and precise quantification has been a roadblock. However, recent progress in the development of intracellular labile iron probes are allowing the reevaluation of our current understanding and unmasking new functions. The role of intracellular labile iron in regulating the epigenome was recently discovered. This chapter examine how intracellular labile iron can modulate histone and DNA demethylation and how its pool can mediate a signaling pathway from cAMP serving as a sensor of the metabolic needs of the cells.
铁是细胞功能所必需的微量元素，但会产生高反应性的氧自由基，导致氧化损伤。出于这些原因，其摄取和代谢受到高度调控。细胞内一小部分亚铁（称为细胞内可利用铁）具有氧化还原反应性，随时准备参与多种细胞内酶的反应。由于其性质，其测定和精确定量一直是一个障碍。然而，细胞内可利用铁探针的最新发展正在允许重新评估我们当前的理解并揭示新的功能。细胞内可利用铁在调节表观基因组中的作用最近被发现。本章探讨了细胞内可利用铁如何调节组蛋白和 DNA 的去甲基化，以及其池如何介导从 cAMP 发出的信号通路，作为细胞代谢需求的传感器。
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