Department of Hepatobiliary Surgery, Kailuan General Hospital, Tangshan, China.
Graduate School of North China University of Science and Technology, Tangshan, China.
Cancer Res Treat. 2021 Oct;53(4):1113-1122. doi: 10.4143/crt.2020.817. Epub 2021 Jan 19.
The influence of fasting blood glucose (FBG) and cholesterolemia primary liver cancer (PLC) in china was analyzed via a large prospective cohort study based on a community population, and the combined effects between them were investigated.
Overall, 98,936 staff from the Kailuan Group who participated in and finished physical examinations between 2006 and 2007 were included in the cohort study. Their medical information was collected and they were followed up after examination. The correlations of serum FBG or total cholesterol (TC) with PLC were analyzed. Then, we categorized all staff into four groups: normal FBG/non-hypocholesterolemia, normal FBG/hypocholesterolemia, elevated FBG/non-hypocholesterolemia, elevated FBG/hypocholesterolemia, and normal FBG/non-hypocholesterolemia was used as a control group. The combined effects of elevated FBG and hypocholesterolemia with PLC were analyzed using the Age-scale Cox proportional hazard regression model.
During 1,134,843.68 person-years follow-up, a total of 388 PLC cases occurred. We found the elevated FBG and hypocholesterolemia increase the risk for PLC, respectively. Compared with the non-hypocholesterolemia/normal FBG group, the risk of PLC was significantly increased in the non-hypocholesterolemia/elevated FBG group (hazard artio [HR], 1.19; 95% confidence interval [CI], 0.88 to 1.62) and hypocholesterolemia/normal FBG group (HR, 1.53; 95% CI, 1.19 to 1.97), and in the hypocholesterolemia/elevated FBG group (HR, 3.16; 95% CI, 2.13 to 4.69). And, a significant interaction effect was found of FBG and TC on PLC. All results were independent from the influence of liver disease.
Elevated serum FBG and hypocholesterolemia are risk factors for PLC, especially when combined. Thus, for the prevention and treatment of PLC, serum FBG and TC levels should be investigated.
通过一项基于社区人群的大型前瞻性队列研究，分析空腹血糖（FBG）和胆固醇对中国原发性肝癌（PLC）的影响，并探讨两者之间的联合作用。
共纳入 2006 年至 2007 年参加并完成体检的开滦集团 98936 名员工进行队列研究。收集他们的医疗信息，并在检查后进行随访。分析血清 FBG 或总胆固醇（TC）与 PLC 的相关性。然后，我们将所有员工分为四组：正常 FBG/非低胆固醇血症、正常 FBG/低胆固醇血症、高 FBG/非低胆固醇血症、高 FBG/低胆固醇血症，正常 FBG/非低胆固醇血症作为对照组。采用 Age-scale Cox 比例风险回归模型分析高 FBG 和低胆固醇血症与 PLC 的联合作用。
在 1134843.68 人年的随访期间，共发生 388 例 PLC 病例。我们发现高 FBG 和低胆固醇血症分别增加了 PLC 的风险。与非低胆固醇血症/正常 FBG 组相比，非低胆固醇血症/高 FBG 组（危险比 [HR]，1.19；95%置信区间 [CI]，0.88 至 1.62）和低胆固醇血症/正常 FBG 组（HR，1.53；95%CI，1.19 至 1.97）的 PLC 风险显著增加，而低胆固醇血症/高 FBG 组（HR，3.16；95%CI，2.13 至 4.69）。并且，还发现 FBG 和 TC 对 PLC 存在显著的交互作用。所有结果均不受肝病影响。
血清 FBG 升高和胆固醇降低是 PLC 的危险因素，尤其是两者同时存在时。因此，在预防和治疗 PLC 时，应检查血清 FBG 和 TC 水平。
