Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Korea.
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02453, Korea.
Molecules. 2021 Jan 21;26(3):548. doi: 10.3390/molecules26030548.
Oxaliplatin is a platinum derivative chemotherapeutic drug widely used against cancers, but even a single treatment can induce a severe allodynia that requires treatment interruption and dose diminution. The rhizome of roscoe (, ginger), has been widely used in traditional medicine to treat various diseases causing pain; however, its effect against oxaliplatin-induced neuropathic pain has never been assessed. In mice, a single oxaliplatin (6 mg/kg, i.p.) treatment induced significant cold and mechanical allodynia. Cold and mechanical allodynia were assessed by acetone drop and von Frey filament tests, respectively. Water extracts of (100, 300, and 500 mg/kg, p.o.) significantly attenuated both cold and mechanical allodynia induced by oxaliplatin. Intrathecal pre-treatment with the antagonist 5-HT (NAN-190, i.t., 1 μg), but not with the antagonist 5-HT (ketanserin, i.t., 1 μg), significantly blocked the analgesic effect of against both cold and mechanical allodynia. However, 5-HT antagonist (MDL-72222, i.t., 15 μg) administration only blocked the anti-allodynic effect of against cold allodynia. Real-time PCR analysis demonstrated that significantly increased the mRNA expression of the spinal 5-HT receptor that was downregulated after oxaliplatin injection. These results suggest that may be a viable treatment option for oxaliplatin-induced neuropathic pain.
奥沙利铂是一种广泛用于治疗癌症的铂类衍生物化疗药物，但即使单次治疗也会引起严重的痛觉过敏，需要中断治疗和减少剂量。独活（独活）的根茎在传统医学中被广泛用于治疗各种引起疼痛的疾病；然而，其对奥沙利铂诱导的神经病理性疼痛的作用从未被评估过。在小鼠中，单次奥沙利铂（6mg/kg，腹腔注射）治疗可引起明显的冷和机械性痛觉过敏。冷和机械性痛觉过敏分别通过丙酮滴注和 von Frey 细丝试验进行评估。独活的水提取物（100、300 和 500mg/kg，口服）显著减轻了奥沙利铂引起的冷和机械性痛觉过敏。鞘内预先给予 5-HT 拮抗剂（NAN-190，鞘内，1μg），但不是 5-HT 拮抗剂（酮色林，鞘内，1μg），显著阻断了 对冷和机械性痛觉过敏的镇痛作用。然而，5-HT 拮抗剂（MDL-72222，鞘内，15μg）给药仅阻断了 对冷痛觉过敏的抗痛觉过敏作用。实时 PCR 分析表明，独活显著增加了脊髓 5-HT 受体的 mRNA 表达，奥沙利铂注射后该受体下调。这些结果表明，独活可能是奥沙利铂诱导的神经病理性疼痛的一种可行治疗选择。
