Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Chitkara College of Pharmacy, Chitkara University, Punjab,India.
Mini Rev Med Chem. 2021;21(20):3074-3096. doi: 10.2174/1389557521666210120112814.
Major approach in controlling as well as eradicating the cancerous growth is through radiotherapy, but this treatment leads to toxicity in the normal cells, leading to secondary malignancies, teratogenesis, and necrosis. More than 15,000 malignancies occur due to exposure to harmful radiations during computed tomography scans. Natural products are non-toxic; there have been reports that herbal products, when given along with radiation, have shown increased tumor control property. The discussed agents in this review have potential antioxidant, immunomodulatory, free radical scavenging, metal chelating, and anti-inflammatory properties.
To reduce the chances of toxicity, reduction in radiation dose or reducing the frequency of the therapy is made which usually leads to a therapeutically poor outcome. The most feasible method is to protect the normal cells by administration of radioprotective agents either before or after the exposure. These agents have been tested on animals and human cell models for evaluating their safety window and toxicity profile at the cellular level. The study aims to compile the effective natural radioprotective agents available, which can be further exploited by using certain QSAR studies to increase their potency.
Structured literature search from EMBASE, PubMed, Bentham Science, Scopus, and ScienceDirect was carried out and appropriate peer-reviewed review articles, as well as certain research articles, were included and compiled in this review paper.
As various studies have indicated the harmful effects of ionizing radiations on normal cells, to reduce these effects, radioprotective agents are used before or after exposure to radiations. Compounds derived from natural sources are proved to have few side effects and they possess radioprotective property due to the presence of alkaloids, resins, volatile oils, tannins in their molecular structure. Various plants having such radioprotective constitutes have been identified for their radioprotective action and compiled in the present study.
控制和根除癌细胞生长的主要方法是通过放疗，但这种治疗会导致正常细胞中毒，导致继发性恶性肿瘤、致畸和坏死。由于在计算机断层扫描期间暴露于有害辐射，超过 15000 种恶性肿瘤发生。天然产物无毒；有报道称，当与辐射一起使用草药产品时，显示出增加的肿瘤控制特性。本文讨论的药物具有潜在的抗氧化、免疫调节、自由基清除、金属螯合和抗炎特性。
为了降低毒性的可能性，可以减少辐射剂量或减少治疗的频率，这通常会导致治疗效果不佳。最可行的方法是通过给予辐射防护剂来保护正常细胞，无论是在暴露之前还是之后。这些药物已在动物和人类细胞模型上进行了测试，以评估其在细胞水平上的安全性窗口和毒性特征。本研究旨在编译现有的有效天然辐射防护剂，可通过使用某些 QSAR 研究来增加其效力。
从 EMBASE、PubMed、Bentham Science、Scopus 和 ScienceDirect 进行了结构化文献检索，并纳入和编译了适当的同行评议综述文章以及某些研究文章。
由于各种研究表明电离辐射对正常细胞的有害影响，为了减少这些影响，在暴露于辐射之前或之后使用辐射防护剂。从天然来源中提取的化合物由于其分子结构中存在生物碱、树脂、挥发油、单宁，因此具有较少的副作用，并且具有辐射防护特性。已经确定了具有这种辐射防护成分的各种植物，以研究其辐射防护作用，并在本研究中进行了编译。
